Recombinant Mouse TNFRSF12A/TWEAK R/CD266 Protein

Tumor necrosis factor receptor superfamily member 12A(Tnfrsf12a) is a single-pass type I membrane protein and contains1 TNFR-Cys repeat. It is weak inducer of apoptosis in some cell types.It promotes angiogenesis and it is the proliferation ofendothelial cells. It may modulate cellular adhesion to matrix proteins.TNFR binds specifically to tumor necrosis factor(TNF) and blocks its interaction with cell surface TNF receptors. TNF is a naturally occurring cytokine that is involved innormal inflammatory and immune responses. It plays an important role in the inflammatory processes of rheumatoidarthritis (RA), polyarticular-course juvenile rheumatoid arthritis (JRA), and ankylosing spondylitis and the resulting jointpathology. In addition, TNF plays a role in the inflammatory process of plaque psoriasis. Elevated levels of TNF are found ininvolved tissues and fluids of patients with RA, psoriatic arthritis, ankylosing spondylitis (AS), and plaque psoriasis. Twodistinct receptors for TNF (TNFRs), a 55 kilodalton protein (p55) and a 75 kilodalton protein (p75), exist naturally asmonomeric molecules on cell surfaces and in soluble forms. Biological activity of TNF is dependent upon binding to eithercell surface TNFR.

Proteins

Glu28-Trp79

Bio-Markers & CD Antigens

Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.Contact us for customized product form or formulation.