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Osteoprotegerin Recombinant Protein

Osteoprotegerin Recombinant Protein

ArtNr	PRS-96-739-0.1mg
Hersteller	ProSci
Menge	0.1 mg
Kategorie	Oncology Metabolism Glucose Homeostasis Peptides & Proteins Recombinant Proteins Western Blot By Organ Lymphatic System Cancer
Typ	Proteins Recombinant
Format	Lyophilized
Applikationen	WB
Specific against	other
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	TNFRSF11B, OCIF, OPG, Osteoprotegerin
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Applications	This recombinant protein can be used for WB. For research use only.
Applications	This recombinant protein can be used for WB. For research use only.
Buffer	PBS, pH7.4
Storage Conditions	Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Disclaimer	Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.
Predicted Molecular Weight	44.4 kDa
Purity	>95% as determined by SDS-PAGE.
Background	Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B) is also known as Osteoclastogenesis inhibitory factor (OCIF), Osteoprotegerin (OPG). TNFRSF11B is a secreted homodimer protein, which can interact with TNFSF10 and TNFSF11. TNFRSF11B acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. TNFRSF11B inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.
1St Image Caption3	Human Osteoprotegerin, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
Background References 1	Tsuda E., et al, 1997, Biochem. Biophys. Res. Commun. 234:137-142.
Background References 2	Emery J.G., et al., 1998, J. Biol. Chem. 273:14363-14367.
Background References 3	Luan X., et al., 2012, J. Immunol. 189:245-252.
Accession #	NP_002537
Ncbi Gene Id #	4982
Ncbi Official Symbol	TNFRSF11B
Ncbi Official Full Name	tumor necrosis factor receptor superfamily, member 11b
Ncbi Organism	Homo sapiens
Swissprot #	O00300
Fusion Tag	His Tag
Sequence	Glu 22 - Leu 401
Biological Activity	Measured by its binding ability in a functional ELISA. Immobilized rh TNFRSF11B at 10μ g/ml (100μ l/well) can bind human TNFSF11 Fc Chimera with a linear ranger of 4-256 ng/mL.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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Menge: 0.1 mg

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Lieferung vsl. bis 06.09.2024

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