ArtNr |
PRS-96-334-0.1mg |
Hersteller |
ProSci
|
Menge |
0.1 mg |
Kategorie |
|
Typ |
Proteins Recombinant |
Format |
Lyophilized |
Applikationen |
WB |
Specific against |
other |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Alias |
FZD5, Frizzled-5, C2orf31, , Fz-5, hFz5, FzE5 |
Lieferbar |
|
Applications |
This recombinant protein can be used for WB. For research use only. |
Applications |
This recombinant protein can be used for WB. For research use only. |
Buffer |
PBS, pH 7.4 |
Storage Conditions |
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles. |
Disclaimer |
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures. |
Predicted Molecular Weight |
42.6 kDa |
Purity |
>95% as determined by SDS-PAGE. |
Background |
Frizzled-5 (FZD5) is also known as FzE5, which belongs to the G-protein coupled receptor Fz/Smo family. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. FZD5 contains one FZ (frizzled) domain. FZD5 may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. FZD5 interacts specifically with Wnt5A to induce the beta-catenin pathway. FZD5 interacts with GOPC. |
1St Image Caption3 |
The purity of rh FZD5 / Frizzled-5 Fc Chimera was determined by DTT-reduced (+) SDS-PAGE and staining overnight with Coomassie Blue. |
Background References 1 |
Hsieh J.C., et al., 1999, Proc. Natl. Acad. Sci. U.S.A. 96:3546-3551. |
Background References 2 |
Hao H.X., et al., 2012, Nature 485:195-200. |
Accession # |
Q13467 |
Ncbi Gene Id # |
7855 |
Ncbi Official Symbol |
FZD5 |
Ncbi Official Full Name |
frizzled class receptor 5 |
Ncbi Organism |
Homo sapiens |
Swissprot # |
Q13467 |
Fusion Tag |
C-Fc Tag |
Sequence |
Ala 27 - Pro 167 |
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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.