ArtNr |
PRS-90-243-10ug |
Hersteller |
ProSci
|
Menge |
10 ug |
Kategorie |
|
Typ |
Proteins Recombinant |
Format |
Lyophilized |
Specific against |
other |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Alias |
ACRP30headless:APRIL, ACRP30headless:CD256, ACRP30headless:TNFSF13, ACRP30headless:A-proliferation-inducing Ligand: |
Lieferbar |
|
Applications |
This recombinant proteins is for research use only. |
Applications |
This recombinant proteins is for research use only. |
Buffer |
Contains PBS + 0.5% Trehalose. Reconstitute with 100 μ l sterile water. |
Storage Conditions |
Stable for at least 6 months after receipt when stored at -20˚ C. |
Disclaimer |
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures. |
Purity |
>95% (SDS-PAGE).
Endotoxin level is less than 0.01EU/ μ g purified protein (LAL test; Lonza). |
Background |
APRIL is a cytokine that belongs to the TNF superfamily and binds to TACI and BCMA. It is implicated in the regulation of tumor cell growth, is involved in monocyte/macrophage-mediated immunological processes and functions as an important survival factor for plasmablasts and bone marrow plasma cells. MultimericAPRIL™ is a high activity construct in which two trimeric APRIL ligands are artificially linked via the collagen domain of ACRP30. This construct very effectively stimulates proliferation B cell. A basic amino acid sequence (QKQKKQ) close to the NH2 terminus of APRIL is required for binding to negatively charged sulfated glycosaminoglycan side chains of proteoglycans. Proteoglycans mediate binding of APRIL to tumor cells as well as primary lymphoid cells. |
Concentration |
0.1mg/ml after reconstitution. |
Accession # |
Q9D777 |
Ncbi Gene Id # |
69583 |
Ncbi Official Symbol |
Tnfsf13 |
Ncbi Official Full Name |
tumor necrosis factor (ligand) superfamily, member 13 |
Ncbi Organism |
Mus musculus |
Swissprot # |
Q8WWA0 |
Fusion Tag |
DDDDK Tag |
Sequence |
The extracellular domain of mouse APRIL (aa 98-232) is fused at the N-terminus to mouse ACRP30headless (aa 18-110) and a DDDDK-tag. |
Biological Activity |
Stimulates B cell proliferation. |
Protein Gi# |
21363035 |
Hinweis: Die dargestellten Informationen und Dokumente (Bedienungsanleitung, Produktdatenblatt, Sicherheitsdatenblatt und Analysezertifikat) entsprechen unserem letzten Update und sollten lediglich der Orientierung dienen. Wir übernehmen keine Garantie für die Aktualität. Für spezifische Anforderungen bitten wir Sie, uns eine Anfrage zu stellen.
Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.