ArtNr |
PRS-11-389-0.1mg |
Hersteller |
ProSci
|
Menge |
0.1 mg |
Kategorie |
|
Typ |
Proteins Recombinant |
Format |
Lyophilized |
Applikationen |
WB, ELISA |
Specific against |
other |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Alias |
GM-CSF R alpha,GM-CSF-R-alpha,GMCSFR-alpha,GMR-alpha,CSF2RA,CSF2R,CSF2RY,CDw116,CD116 |
Lieferbar |
|
Applications |
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 60.9 kDa. The protein migrates as 70-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Applications |
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 60.9 kDa. The protein migrates as 70-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Buffer |
Tris with Glycine, Arginine and NaCl, pH7.5 |
Storage Conditions |
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles. |
Disclaimer |
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures. |
Predicted Molecular Weight |
60.9 kDa |
Purity |
>95% as determined by SDS-PAGE. |
Background |
GM-CSF R alpha(Granulocyte-macrophage colony-stimulating factor receptor subunit alpha) is also known as CSF2RA, CD116, GMR-alpha. Low affinity receptor for granulocyte-macrophage colony-stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells. Hereditary pulmonary alveolar proteinosis (hPAP) is a rare disorder of pulmonary surfactant accumulation and hypoxemic respiratory failure caused by mutations in CSF2RA (encoding the granulocyte/macrophage colony-stimulating factor [GM-CSF] receptor α-chain [CD116]), which results in reduced GM-CSF-dependent pulmonary surfactant clearance by alveolar macrophages. |
1St Image Caption3 |
Human GM-CSF R alpha, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%. |
Background References 1 |
Hetzel M, et al. 2017. Hum Gene Ther Methods. 28(6):318-329. |
Background References 2 |
Wang SL, et al. 2003, Sheng Li Xue Bao. 55(4):487-92. |
Accession # |
NP_006131.2 |
Ncbi Gene Id # |
1438 |
Ncbi Official Symbol |
CSF2RA |
Ncbi Official Full Name |
colony stimulating factor 2 receptor subunit alpha |
Ncbi Organism |
Homo sapiens |
Swissprot # |
P15509 |
Fusion Tag |
Fc Tag |
Sequence |
Glu 23 - Gly 320 |
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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.