CD24 Recombinant Protein

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 5.0 kDa. The protein migrates as 19-33 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.

5.0 kDa

CD24 may have a pivotal role in cell differentiation of different cell types. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Modulates B-cell activation responses. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells. In association with SIGLEC10 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90. Plays a role in the control of autoimmunity.

Suzuki T1, et al. 2001. J Immunol. 166(9):5567-77.

Eyvazi S, et al. 2018. Curr Cancer Drug Targets. 18(4):328-336.

100133941

CD24molecule

P25063

Ser 27 - Gly 59