ArtNr |
PRS-11-224-0.1mg |
Hersteller |
ProSci
|
Menge |
0.1 mg |
Kategorie |
|
Typ |
Proteins Recombinant |
Format |
Lyophilized |
Applikationen |
WB, ELISA |
Specific against |
other |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Alias |
NRG1 Beta 1,HRG1 beta 1,Neuregulin-1 beta 1,Neuregulin1 beta 1,NRG1,ARIA,GGF,HGL,HRGA,NDF,SMDF |
Lieferbar |
|
Applications |
This protein carries a human IgG1 Fc tag at the N-terminus. The protein has a calculated MW of 53.2 kDa. The protein migrates as 65-80 kDa and 90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Applications |
This protein carries a human IgG1 Fc tag at the N-terminus. The protein has a calculated MW of 53.2 kDa. The protein migrates as 65-80 kDa and 90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Buffer |
PBS, pH7.4 |
Storage Conditions |
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles. |
Disclaimer |
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures. |
Predicted Molecular Weight |
53.2 kDa |
Purity |
>90% as determined by SDS-PAGE. |
Background |
NRG1 is one of four proteins in the neuregulin family that act on the EGFR family of receptors. It is known that an extraordinary variety of different isoforms are produced from the NRG1 gene by alternative splicing. These isoforms include heregulins (HRGs), glial growth factors (GGFs) and sensory and motor neuron-derived factor (SMDF). They are tissue-specific and differ significantly in their structure. The HRG isoforms all contain immunoglobulin (Ig) and epidermal growth factor-like (EGF-like) domains. GGF and GGF2 isoforms contain a kringle-like sequence plus Ig and EGF-like domains; and the SMDF isoform shares only the EGF-like domain with other isoforms. The receptors for all NRG1 isoforms are the ERBB family of tyrosine kinase transmembrane receptors. Through their displayed interaction with ERBB receptors, NRG1 isoforms induce the growth and differentiation of epithelial, neuronal, glial, and other types of cells. |
1St Image Caption3 |
Human NRG1 Beta 1, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%. |
3Rd Image Caption |
Immobilized Human ErbB4, His Tag at 2 ug/mL (100 uL/well) can bind Human NRG1 Beta 1, Fc Tag with a linear range of 0.5-8 ng/mL (Routinely tested). |
Background References 1 |
Britsch S. Adv Anat Embryol Cell Biol. 2007. 190:1-65. |
Background References 2 |
Talmage DA. Novartis Found Symp. 2008. 289:74-84. |
Background References 3 |
Orr-Urtreger A, et al. Proc Natl Acad Sci U S A. 1993. 90(5):1867-71. |
Accession # |
NP_039250.2 |
Ncbi Gene Id # |
3084 |
Ncbi Official Symbol |
NRG1 |
Ncbi Official Full Name |
neuregulin1 |
Ncbi Organism |
Homo sapiens |
Swissprot # |
Q02297 |
Fusion Tag |
Fc Tag |
Sequence |
Ser 2 - Lys 246 |
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