ArtNr |
NKM-RAR0801-500ug |
Hersteller |
NKMAX
|
Menge |
500ug |
Kategorie |
|
Typ |
Proteins Recombinant |
Applikationen |
SDS-PAGE |
Specific against |
other |
Konjugat/Tag |
His-Tag |
Purity |
> 95% by SDS-PAGE |
NCBI |
NP_000955 |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Alias |
RAR a, NR1B1, Retinoic acid receptor alpha isoform 1, NR1B1, Retinoic acid receptor alpha, Retinoic acid receptor, alpha isoform 1, RAR alpha, RARalpha, RAR, Retinoic acid receptor, alpha isoform 1 |
Lieferbar |
|
Antigen Species |
Human |
Concentration |
1mg/ml (determined by Bradford assay) |
Description |
Retinoic acid receptors (RAR) belong to the large family of ligand responsive gene regulatory proteins that includes receptors for steroid and thyroid hormones. These proteins contain two highly conserved domains that are involved in determining their DNA and ligand-binding activities. Three isotypes of RARs, alpha, beta, and gamma, are encoded by distinct genetic loci and possess distinct transcriptional properties. Typically, RAR-alpha represses target gene transcription in the absence of hormone, whereas RAR-beta and gamma fail to repress under these conditions. Recombinant human RARalpha, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques. |
Expression System |
E.coli |
Formulation |
Liquid. In Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol, 1mM DTT, 0.1M NaCl |
Gene Category |
Cell Cycle |
General References |
Kliewer SA., et al. (1992) Nature. 355, 446-9.; ; Gillespie RF., et al. (2007) J. Biol. Chem. 282, 33421-34. |
Molecular Weight |
14 kDa (127aa) confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher) |
Storage |
Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles. |
Hinweis: Die dargestellten Informationen und Dokumente (Bedienungsanleitung, Produktdatenblatt, Sicherheitsdatenblatt und Analysezertifikat) entsprechen unserem letzten Update und sollten lediglich der Orientierung dienen. Wir übernehmen keine Garantie für die Aktualität. Für spezifische Anforderungen bitten wir Sie, uns eine Anfrage zu stellen.
Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.