ArtNr |
NKM-ATGP4007-50ug |
Hersteller |
NKMAX
|
Menge |
50ug |
Kategorie |
|
Typ |
Proteins Recombinant |
Applikationen |
SDS-PAGE |
Specific against |
other |
Konjugat/Tag |
hIgG-His-Tag |
Purity |
> 95% by SDS - PAGE |
NCBI |
NP_001241.1 |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Alias |
Bp50, CDW40, p50, TNFRSF5, tumor necrosis factor receptor superfamily member 5 isoform1, B-cell surface antigen CD40, CD40L receptor |
Lieferbar |
|
Antigen Species |
Human |
Bioassay Procedure |
EPPTACREKQ YLINSQCCSL CQPGQKLVSD CTEFTETECL PCGESEFLDT WNRETHCHQH KYCDPNLGLR VQQKGTSETD TICTCEEGWH CTSEACESCV LHRSCSPGFG VKQIATGVSD TICEPCPVGF FSNVSSAFEK CHPWTSCETK DLVVQQAGTN KTDVVCGPQD RLR |
Concentration |
1mg/ml (determined by Absorbance at 280nm) |
Description |
CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily. It transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglubiln secretion. CD40 is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. CD40 molecule is a potential target for cancer immunotherapy. There are number of completed and ongoing clinical trials where agonistic anti-CD40 monoclonal antibodies are employed to activate an anti-tumor T cell response via activation of dendritic cells. Recombinant human CD40, fused to hIgG-His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques. |
Domain |
21-193aa |
Endotoxin |
< 1 EU per 1ug of protein (determined by LAL method) |
Expression System |
HEK293 |
Formulation |
Liquid. In Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol |
Gene Category |
Immunology |
General References |
Vonderheide RH, et al, (2013) Clin Cancer Res. 19:1035-1043.; ; Remer M., et al (2017) Curr Top Microbiol Immunol. 405:165-207.; ; Karnell JL, et al, (2019) Adv Drug Deliv Rev. 141:92-103.; ; |
Molecular Weight |
46.1kDa (412aa) |
Predicted nterm |
Glu 21 |
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