ArtNr |
NKM-ATGP3998-20ug |
Hersteller |
NKMAX
|
Menge |
20ug |
Kategorie |
|
Typ |
Proteins Recombinant |
Applikationen |
SDS-PAGE |
Specific against |
other |
Konjugat/Tag |
hIgG-His-Tag |
Purity |
> 95% by SDS - PAGE |
NCBI |
NP_055072 |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Alias |
CD209L, DC-SIGN2, DCSIGNR, HP10347, L-SIGN, LSIGN, C-type lectin domain family 4 member M, CLEC4M, C-type lectin domain family 4 member M isoform 1, CD209L1, CD299, DC-SIGNR, DC-SIGN2, CD209 antigen-like protein, DC-SIGN-related protein, Dendritic cell-specific ICAM-3-grabbing non-integrin 2, Liver/lymph node-specific ICAM-3-grabbing non-integrin |
Lieferbar |
|
Antigen Species |
Human |
Bioassay Procedure |
VSKVPSS LSQEQSEQDA IYQNLTQLKA AVGELSEKSK LQEIYQELTQ LKAAVGELPE KSKLQEIYQE LTRLKAAVGE LPEKSKLQEI YQELTRLKAA VGELPEKSKL QEIYQELTRL KAAVGELPEK SKLQEIYQEL TELKAAVGEL PEKSKLQEIY QELTQLKAAV GELPDQSKQQ QIYQELTDLK TAFERLCRHC PKDWTFFQGN CYFMSNSQRN WHDSVTACQE VRAQLVVIKT AEEQNFLQLQ TSRSNRFSWM GLSDLNQEGT WQWVDGSPLS PSFQRYWNSG EPNNSGNEDC AEFSGSGWND NRCDVDNYWI CKKPAACFRD E |
Concentration |
0.5mg/ml (determined by Absorbance at 280nm) |
Description |
CD299, as known as DC-SIGNR and CLEC4M, is a type II integral membrane protein that is 77% amino acid identical to CD209/DC-SIGN, an HIV gp120-binding protein. This protein is probable pathogen-recognition receptor involved in peripheral immune surveillance in liver. It may mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. CD299 is a receptor for ICAM3, binding to mannose-like carbohydrates. It also recognizes a wide range of evolutionarily divergent pathogens with a large impact on public health, including tuberculosis mycobacteria, and viruses including Ebola, hepatitis C, HIV-1, influenza A, West Nile virus and the SARS-CoV acute respiratory syndrome coronavirus. Recombinant human CD299, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. |
Domain |
72-399aa |
Endotoxin |
< 1 EU per 1ug of protein (determined by LAL method) |
Expression System |
Baculovirus |
Formulation |
Liquid. In Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol |
Gene Category |
Immunology |
General References |
Gijzen K., et al, (2008) Exp Hematol. 36:860-870.; ; Johnson TR, et al, (2012) J Virol. 86:1339-1347.; ; Xia HB, et al, (2020) Oncol Lett. 19:69-76.; ; |
Molecular Weight |
64.8kDa (570aa) |
Predicted nterm |
Ala |
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