ArtNr |
NKM-ATGP3971-500ug |
Hersteller |
NKMAX
|
Menge |
500ug |
Kategorie |
|
Typ |
Proteins Recombinant |
Applikationen |
SDS-PAGE |
Specific against |
other |
Konjugat/Tag |
hIgG-His-Tag |
Purity |
> 95% by SDS - PAGE |
NCBI |
NP_035789.1 |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Alias |
Tumor necrosis factor receptor superfamily member 4, OX40 antigen, OX40L receptor, CD134, Txgp1, Tnfrsf4, tax-transcriptionally activated glycoprotein 1, TXGP1L, ACT35, Ly-70, ACT3, OX4, Txgp |
Lieferbar |
|
Antigen Species |
Mouse |
Bioassay Procedure |
VTARRL NCVKHTYPSG HKCCRECQPG HGMVSRCDHT RDTLCHPCET GFYNEAVNYD TCKQCTQCNH RSGSELKQNC TPTQDTVCRC RPGTQPRQDS GYKLGVDCVP CPPGHFSPGN NQACKPWTNC TLSGKQTRHP ASDSLDAVCE DRSLLATLLW ETQRPTFRPT TVQSTTVWPR TSELPSPPTL VTPEGP |
Concentration |
0.25mg/ml (determined by Absorbance at 280nm) |
Description |
TNFRSF4, also known as CD134, is a member of the TNFR-superfamily of receptors. It is a receptor for TNFSF4/OX40L/GP34. This protein is a costimulatory molecule implicated in long-term T-cell immunity. The interaction with OX40L regulates antigen-specific T-cell expansion and survival, cytokine production. It also modulates cytokine receptor signalling. Therefore the interaction between TNFRSF4 and CD40L plays a key role in the development of multiple imflammatry and autoimmune disease. Recombinant mouse OX40/TNFRSF4 , fused to hIgG-His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques. |
Domain |
20-211aa |
Endotoxin |
< 1 EU per 1ug of protein (determined by LAL method) |
Expression System |
HEK293 |
Formulation |
Liquid. In Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol |
General References |
Schreiber TH, et al, (2012) J Immunol. 189:3311-3318.; Webb GJ, et al, (2016) Clin Rev Allergy Immunol. 50:312-332.; Zhou B, et al, (2020) Transplant Proc. 52:398-405.; |
Molecular Weight |
48.7kDa (435aa) |
Predicted nterm |
Asp |
Storage |
Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles. |
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