ArtNr |
NKM-ATGP3933-10ug |
Hersteller |
NKMAX
|
Menge |
10ug |
Kategorie |
|
Typ |
Proteins Recombinant |
Applikationen |
SDS-PAGE |
Specific against |
other |
Konjugat/Tag |
His-Tag |
Purity |
> 90% by SDS-PAGE |
NCBI |
NP_112227 |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Alias |
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5, GD1 alpha synthase, GalNAc alpha-2,6-sialyltransferase V, ST6GalNAc V, ST6GalNAcV, Sialyltransferase 7E, SIAT7-E, SIAT7E |
Lieferbar |
|
Antigen Species |
Human |
Bioassay Procedure |
GGQKERP PQQQQQQQQQ QQQASATGSS QPAAESSTQQ RPGVPAGPRP LDGYLGVADH KPLKMHCRDC ALVTSSGHLL HSRQGSQIDQ TECVIRMNDA PTRGYGRDVG NRTSLRVIAH SSIQRILRNR HDLLNVSQGT VFIFWGPSSY MRRDGKGQVY NNLHLLSQVL PRLKAFMITR HKMLQFDELF KQETGKDRKI SNTWLSTGWF TMTIALELCD RINVYGMVPP DFCRDPNHPS VPYHYYEPFG PDECTMYLSH ERGRKGSHHR FITEKRVFKN WARTFNIHFF QPDWKPESLA INHPENKPVF |
Concentration |
0.25mg/ml (determined by absorbance at 280nm) |
Description |
ST6GALNAC5, also known as Alpha-N-acetylgalactosaminide alpha-2, 6-sialyltransferase 5, is a member of the glycosyltransferase 29 family. This protein is a sialyltransferase involved in the biosynthesis of ganglioside GD1a from GM1b. It is involved in the pathway protein glycosylation, which is part of Protein modification. It's expression is restricted to the brain normally. It has been identified as a key player in the metastasis of breast cancer cells to the brain by potentially enabling the cancer cells to cross the blood-brain barrier. Recombinant human ST6GALNAC5, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. |
Domain |
30-336aa |
Endotoxin |
< 1 EU per 1ug of protein (determined by LAL method) |
Expression System |
Baculovirus |
Formulation |
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol |
Gene Category |
Tags & Cell Markers |
General References |
Kolter, T. et al. (2002) J. Biol. Chem. 277:25859-25862.; ; Okajima, T. et al. (1999) J. Biol. Chem.274:30557-30562.; ; Harduin-Lepers, A. et al. (2005) Glycobiology 15:805-817.; ; |
Molecular Weight |
36.4 kDa (316aa) |
Predicted nterm |
Ala39 |
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