ArtNr |
NKM-ATGP2237-100ug |
Hersteller |
NKMAX
|
Menge |
100ug |
Kategorie |
|
Typ |
Proteins |
Applikationen |
SDS-PAGE |
Specific against |
other |
Konjugat/Tag |
His-Tag |
Purity |
> 90% by SDS-PAGE |
NCBI |
NP_001239008 |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Alias |
ubiquitin carboxyl-terminal hydrolase 15 isoform 3, uNPH-2, uNPH4 |
Lieferbar |
|
Antigen Species |
Human |
Bioassay Procedure |
MGSSHHHHHH SSGLVPRGSH MGSMAEGGAA DLDTQRSDIA TLLKTSLRKG DTWYLVDSRW FKQWKKYVGF DSWDKYQMGD QNVYPGPIDN SGLLKDGDAQ SLKEHLIDEL DYILLPTEGW NKLVSWYTLM EGQEPIARKV VEQGMFVKHC KVEVYLTELK LCENGNMNNV VTRRFSKADT IDTIEKEIRK IFSIPDEKET RLWNKYMSNT FEPLNKPDST IQDAGLYQGQ VLVIEQKNED GTWPRGPSTP KKPLEQSC |
Concentration |
0.5mg/ml (determined by Bradford assay) |
Description |
uSP15 is a member of the ubiquitin specific protease (uSP) family of deubiquitinating enzymes. uSP enzymes play critical roles in ubiquitin-dependent processes through polyubiquitin chain disassembly and hydrolysis of ubiquitin-substrate bonds. The protein associates with the COP9 signalosome, and also plays a role in transforming growth factor beta signalling through deubiquitination of receptor-activated SMAD transcription factors. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 2. Recombinant human uSP15 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques. |
Domain |
1-235aa |
Expression System |
E.coli |
Formulation |
Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol, 1mM DTT |
Gene Category |
Epigenomics (Transcription & Translation) |
General References |
Imboden, M., et al. (2012) J. Allergy Clin. Immunol. 129 (5), 1218-1228; ; Eichhorn, P.J., et al. (2012) Nat. Med. 18 (3), 429-435 |
Molecular Weight |
29.5 kDa (258aa) confirmed by MALDI-TOF |
Storage |
Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles. |
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