Recombinant human PHF11 protein

Human

PHD finger protein 11, also known as PHF11, is a regulator of TH1-type cytokine gene expression. The reduction in PHF11 expression seen with an AD-associated genotype could contribute to the strong TH2 responses that characterize many allergic individuals. PHF11 are associated with increased total serum IgE levels, asthma, and severe atopic dermatitis (AD) in children. Although PHF11 includes a plant homeodomain, a motif often found in transcriptional regulators, the function of PHF11 has not been investigated. Recombinant human PHF11 protein, fused to His-tag at N-terminus, was expressed in E. coli.

Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol

Clarke E., et al. (2008) J. Allergy Clin. Immunol. 121:1148-1154; ; Scanlan M.J., et al. (1999) Int. J. Cancer. 83:456-464; ;

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.