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Recombinant human DNA polymerase beta/POLB protein

ArtNr NKM-ATGP1190-500ug
Hersteller NKMAX
Menge 500 ug
Quantity options 100 ug 20 ug 500 ug
Kategorie
Typ Proteins Recombinant
Format Liquid
Applikationen SDS-PAGE
Specific against Human (Homo sapiens)
Host E.coli
Konjugat/Tag HIS
Purity > 95% by SDS-PAGE
Sequence <MGSSHHHHHH SSGLVPRGSH> MSKRKAPQET LNGGITDMLT ELANFEKNVS QAIHKYNAYR KAASVIAKYP HKIKSGAEAK KLPGVGTKIA EKIDEFLATG KLRKLEKIRQ DDTSSSINFL TRVSGIGPSA ARKFVDEGIK TLEDLRKNED KLNHHQRIGL KYFGDFEKRI PREEMLQMQD IVLNEVKKVD SEYIATVCGS FRRGAESSGD MDVLLTHPSF TSESTKQPKL
Citations Bambara R A., et al. (1991) Biochim Biophys Acta. 1088:11-24.
Ropp P A., et al. (1996) Genomics. 36:449-458.
NCBI NP_002681.1
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Alias DNA polymerase beta,DNA directed DNA polymerase beta,Polymerase (DNA directed) beta,DNA pol beta,DNA polymerase beta subunit,MGC125976,Pol B,Pol beta
Similar products POLB, DNA polymerase beta, DNA pol beta, DNA polymerase beta subunit, DNA directed DNA polymerase beta, MGC125976, Pol B, Pol beta, Polymerase (DNA directed) beta, PolB, ATGP1190-10ug, ATGP1190-20ug, ATGP1190-50ug, ATGP1190-100ug, ATGP1190-250ug, ATGP1190-500ug, ATGP1190-1mg, ATGP1190-10, ATGP1190-20, ATGP1190-50, ATGP1190-100, ATGP1190-250, ATGP1190-500, ATGP1190-1
Lieferbar
Manufacturer - Type
Recombinant Protein
Storage Conditions
Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Molecular Weight
40.3 kDa (355aa) confirmed by MALDI-TOF
Description
DNA polymerase beta, also known as POLB, belongs to the DNA polymerase type-X family. In eukaryotic cells, DNA polymerase beta (POLB) performs base excision repair (BER) required for DNA maintenance, replication, recombination, and drug resistance. POLB has two distinct domains, the larger is the polymerase domain itself, whereas a small basic N-terminal domain contains an AP lyase activity that excises the abasic sugar-phosphate residue at the strand break. POLB fills single nucleotide gaps in DNA produced by the base excision repair pathway of mammalian cells. Overexpression of POLB, as found in some human tumors, could confer an increase in spontaneous mutagenesis. Recombinant human POLB protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Concentration
0.5mg/ml (determined by Bradford assay)
Formulation
Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 30% glycerol, 0.1M NaCl
Antigen Species
Human
Gene Category
Enzymes & Proteases
Domain
1-335aa
Species of Protein
Human
Manufacturer - Search Terms
POLB, DNA polymerase beta, DNA directed DNA polymerase beta, DNA pol beta, DNA polymerase beta, DNA polymerase beta subunit, MGC125976, Pol B, Pol beta, PolB, Polymerase (DNA directed) beta, ATGP1190-10ug, ATGP1190-20ug, ATGP1190-50ug, ATGP1190-100ug, ATGP1190-250ug, ATGP1190-500ug, ATGP1190-1mg, ATGP1190-10, ATGP1190-20, ATGP1190-50, ATGP1190-100, ATGP1190-250, ATGP1190-500, ATGP1190-1

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 500 ug
Lieferbar: In stock
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