Recombinant human NQO-1 protein

Human

NQO1 is a member of the NAD (P) H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This protein apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis. NQO1 functions as an important part of cellular antioxidant defense by detoxifying quinines thus preventing the formation of reactive oxygen species. Altered expression of NQO1 has been seen in many tumors and is also associated with Alzheimer's disease (AD). Recombinant NQO1 protein was expressed in E. coli and purified by using conventional chromatography techniques

Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 10% glycerol 1mM DTT

Jaiswal AK., et al. (1988) J Biol Chem. 263(27):13572-8. ; ; Traver RD., et al. (1992) Cancer Res. 52(4):797-802.; ;

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.