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Human Mesothelin / MSLN (37-286) Protein, His Tag

Human Mesothelin / MSLN (37-286) Protein, His Tag

ArtNr	MSN-H5222-1mg
Hersteller	ACROBiosystems
Menge	500 ug x 2
Quantity options	100 ug 500 ug x 2
Kategorie	Peptides & Proteins Recombinant Proteins
Typ	Proteins Recombinant
Format	Powder
Specific against	Human (Homo sapiens)
Host	HEK293
Konjugat/Tag	Unconjugated, HIS
Purity	95%
Citations	(1) Chang K., et al., 1996, Proc. Natl. Acad. Sci. U.S.A. 93:136-140. (2) Yamaguchi N., et al., 1994, J. Biol. Chem. 269:805-808. (3) Rump A., et al., 2004, J. Biol. Chem. 279:9190-9198. (4) Ma J., et al., 2012, J. Biol. Chem. 287:33123-33131.
NCBI	AAH09272
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	MSLN,Mesothelin,MPF
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Category	Protein / Bio-Markers & CD Antigens
Manufacturer - Conjugate / Tag	Unconjugated, C-6xHis
Shipping Temperature	RT
Storage Conditions	-20°C
Molecular Weight	27.5 kDa
Description	Human Mesothelin (37-286), His Tag (MSN-H5222) is expressed from human 293 cells (HEK293). It contains AA Leu 37 - Arg 286 (Accession # AAH09272).
Background	Mesothelin (MSLN) is also known as CAK1 antigen, Pre-pro-megakaryocyte-potentiating factor, which belongs to the mesothelin family. Mesothelin / MSLN can be proteolytically cleaved into the following two chains by a furin-like convertase: Megakaryocyte-potentiating factor (MPF) and the cleaved form of mesothelin. Both MPF and the cleaved form of mesothelin are N-glycosylated. Mesothelin / MSLN can interacts with MUC16. The membrane-anchored forms of MSLN may play a role in cellular adhesion. MPF potentiates megakaryocyte colony formation in vitro.
Molecule	Mesothelin
Exp Region	Leu 37 - Arg 286
Characteristics	This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 27.5 kDa. The protein migrates as 32 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin	1.0 EU per μg
Buffer	PBS, pH7.4
Stability	● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution.For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Protectant	trehalose

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MSN-H5222-1mg-datasheet.pdf

MSN-H5222-1mg-safety-datasheet.pdf