ArtNr |
KMD-MOP2074-50ug |
Hersteller |
KMD Bioscience
|
Menge |
50 ug |
Kategorie |
|
Typ |
Proteins Recombinant |
Specific against |
Mouse |
Host |
Mammalian cell |
Konjugat/Tag |
His |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Alias |
B7, B70, MB7, B7-2, B7.2, CLS1, Ly58, ETC-1, Ly-58, MB7-2, Cd28l2, TS/A-2, CD86 antigen |
Lieferbar |
|
Molecular Name |
Cd86 |
Source |
This protein contains the mouse Cd86(Val24-Lys244) was fused with the C-terminal His Tag and expressed in Mammalian cells. |
Uniprot Accession |
P42082 |
Purity |
>=90% as determined by SDS-PAGE |
Endotoxin |
< 1.0 EU per ug of the protein as determined by the LAL method. |
Buffer |
PBS |
Purification |
Protein A/G |
Predicted Molecular Weight |
24.31kDa |
Background |
B7-1 and B7-2, together with their receptors CD28 and CTLA-4, constitute one of the dominant costimulatory pathways that regulate T- and B-cell responses. Although both CTLA-4 and CD28 can bind to the same ligands, CTLA-4 binds to B7-1 and B7-2 with a 2 - 1 fold higher affinity than CD28 and is involved in the down-regulation of the immune response. B7-1 is expressed on activated B cells, activated T cells, and macrophages. B7-2 is constitutively expressed on interdigitating dendritic cells, Langerhans cells, peripheral blood dendritic cells, memory B cells, and germinal center B cells. |
Storage |
Store the product under sterile conditions after opening at -20C to -80C for 12 months. Avoid repeated freeze-thaw cycles. |
Shipping Condition |
This product is shipped on ice packs or dry ice. |
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