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Human Integrin alpha 6 beta 1 (ITGA6&ITGB1) Heterodimer Protein, His Tag&Tag Free Europäischer Partner

ArtNr IT1-H52W7-100ug
Hersteller ACROBiosystems
Menge 100 ug
Quantity options 100 ug 100 ug x 10
Kategorie
Typ Proteins Recombinant
Format Powder
Specific against Human (Homo sapiens)
Host HEK293
Konjugat/Tag Unconjugated, HIS
Purity 90%
Citations (1) Tachibana I, et al., 1997, The Journal of Biological Chemistry, 272 (46): 29181-29189. (2) Tani TT, et al., 2001, The Journal of Biological Chemistry, 276 (39): 36535-36542. (3) Lipscomb EA, etal., 2005, Cancer Metastasis Reviews, 24 (3): 413-423.
NCBI NP_000201.2 (ITGA6) , NP_002202.2 (ITGB1)
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Alias Integrin alpha 6 beta 1,ITGA6&ITGB1
Versandbedingung Raumtemperatur
Lieferbar
Manufacturer - Category
Protein / Bio-Markers & CD Antigens
Manufacturer - Conjugate / Tag
Unconjugated, C-10xHis | Native
Shipping Temperature
RT
Storage Conditions
-20°C
Molecular Weight
116.8 kDa (ITGA6) & 83.7 kDa (ITGB1)
Description
Human ITGA6&ITGB1 Heterodimer Protein, His Tag&Tag Free (IT1-H52W7) is expressed from human 293 cells (HEK293). It contains AA Phe 24 - Gly 1012 (ITGA6) & Gln 21 - Asp 728 (ITGB1) (Accession # P23229-2 (ITGA6) & P05556-1 (ITGB1)).
Background
Integrin alpha 6 beta 1, also called platelet glycoprotein GPIc-IIa, is a receptor for laminin on platelets. The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. ITGA6 has been shown to interact with TSPAN4 and GIPC1.
Molecule
Integrin alpha 6 beta 1
Exp Region
Phe 24 - Gly 1012 (ITGA6) & Gln 21 - Asp 728 (ITGB1)
Characteristics
Human ITGA6&ITGB1 Heterodimer Protein, His Tag&Tag Free, produced by co-expression of ITGA6 and ITGB1, has a calculated MW of 116.8 kDa (ITGA6) and 83.7 kDa (ITGB1). Subunit ITGA6 is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and subunit ITGB1 contains no tag but a basic tail at the C-terminus. The non-reducing (NR) protein migrates as 140-150 kDa (ITGA6) and 100-118 kDa (ITGB1) respectively due to glycosylation.
Endotoxin
1.0 EU per μg
Buffer
50 mM Tris, 150 mM NaCl, pH7.5
Stability
● -20°C to -70°C for 12 months in lyophilized state;
● -70°C for 3 months under sterile conditions after reconstitution.For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Protectant
trehalose

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 100 ug
Lieferbar: In stock
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