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Human Integrin alpha 5 beta 1 (ITGA5&ITGB1) Heterodimer Protein, His Tag&Tag Free

Human Integrin alpha 5 beta 1 (ITGA5&ITGB1) Heterodimer Protein, His Tag&Tag Free

ArtNr	IT1-H52W5-100ug
Hersteller	ACROBiosystems
Menge	100 ug
Quantity options	100 ug 200 ug x 5
Kategorie	Peptides & Proteins Recombinant Proteins
Typ	Proteins Recombinant
Format	Powder
Specific against	Human (Homo sapiens)
Host	HEK293
Konjugat/Tag	Unconjugated, HIS
Purity	95%
Citations	(1) Wei Xia., et al., 2014, Proc Natl Acad Sci U S A. 111(50): 17863-17868. (2) Masamichi N., et al., 2012, J Cell Biol. 197(1): 131-140. (3) Takagi J., et al., 2003, EMBO J. 22(18):4607-15.
NCBI	NP_002196.4 (ITGA5) , NP_002202.2 (ITGB1)
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Integrin alpha 5 beta 1,ITGA5&ITGB1
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Category	Protein / Bio-Markers & CD Antigens
Manufacturer - Conjugate / Tag	Unconjugated, C-10xHis \| Native
Shipping Temperature	RT
Storage Conditions	-20°C
Molecular Weight	110.7 kDa (ITGA5) & 83.7 kDa (ITGB1)
Description	Human ITGA5&ITGB1 Heterodimer Protein, His Tag&Tag Free (IT1-H52W5) is expressed from human 293 cells (HEK293). It contains AA Phe 42 - Tyr 995 (ITGA5) & Gln 21 - Asp 728 (ITGB1) (Accession # P08648-1 (ITGA5) & P05556-1 (ITGB1)).
Background	Integrin alpha 5 beta 1 / Integrin α5β1, which is a major cellular receptor for the extracellular matrix protein fibronectin and plays a fundamental role during mammalian development., is composed of α5 (ITGA5/CD49e) and β1 (ITGB1/CD29) subunits. Integrins are adhesion receptors that transmit bidirectional signals across the plasma membrane. The Integrin alpha 5 beta 1 and its primary extracellular matrix ligand fibronectin (Fn) are of great biological importance.
Molecule	Integrin alpha 5 beta 1
Exp Region	Phe 42 - Tyr 995 (ITGA5) & Gln 21 - Asp 728 (ITGB1)
Characteristics	Human ITGA5&ITGB1 Heterodimer Protein, His Tag&Tag Free, produced by co-expression of ITGA5 and ITGB1, has a calculated MW of 110.7 kDa (ITGA5) and 83.7 kDa (ITGB1). Subunit ITGA5 is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and subunit ITGB1 contains no tag but a basic tail at the C-terminus. The non-reducing (NR) protein migrates as 130-150 kDa (ITGA5) and 100-120 kDa (ITGB1) when calibrated against Star Ribbon Pre-stained Protein Marker respectively due to glycosylation.
Endotoxin	1.0 EU per μg
Buffer	50 mM Tris, 150 mM NaCl, pH7.5
Stability	● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution.For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Protectant	trehalose

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Arbeitsanleitung (Data Sheet) anfordern

IT1-H52W5-100ug-datasheet.pdf

IT1-H52W5-100ug-safety-datasheet.pdf