ArtNr |
ILA-H82H5-25ug |
Hersteller |
ACROBiosystems
|
Menge |
25 ug |
Kategorie |
|
Typ |
Proteins Recombinant |
Format |
Powder |
Specific against |
Human |
Host |
HEK293 |
Konjugat/Tag |
Biotin, HIS, Avi |
Purity |
90% |
Citations |
(1) Mardiros A., et al. 2013, Blood., 122(18), 3138-48. (2) Rapoport AP., et al. 1996, Blood., 87(1), 112-22. (3) Klöß S., et al. 1996, Hum Gene Ther., 28(10), 897-913. |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Alias |
IL3R,IL3RA,IL-3Ra,IL-3R-alpha,IL3RAY,IL3RX,IL3RY,CD123 antigen,CD123,hIL3Ra,hIL-3Ra,MGC34174,IL-3 R alpha |
Lieferbar |
|
Manufacturers Category |
Protein / MABSol® Biotin Labeled Proteins |
Description |
Biotinylated Human IL-3 R alpha Protein, His, Avitag, premium grade (ILA-H82H5) is expressed from human 293 cells (HEK293). It contains AA Thr 19 - Arg 305 (Accession # P26951-1). |
Molecule |
IL-3 R alpha |
Exp Region |
Thr 19 - Arg 305 |
Storage |
-20℃ |
Shipping |
RT |
Stability |
-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution.
For long term storage, the product should be stored at lyophilized state at -20°C or lower. |
Molecular Weight |
36.7 kDa |
Characteristics |
This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag™). The protein has a calculated MW of 36.7 kDa. The protein migrates as 57 kDa±3 kDa under reducing (R) condition, and 54 kDa±3 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under non-reducing (NR) condition (SDS-PAGE) due to glycosylation. |
Endotoxin |
0.01 EU per μg |
Buffer |
PBS, pH7.4 |
Background |
Interleukin 3 receptor alpha (low affinity) (IL3RA), also known as CD123 (Cluster of Differentiation 123) is a 70-kD glycoprotein member of the hematopoietin receptor superfamily. This protein associates with a beta subunit common to the receptors for IL-5 and granulocyte-macrophage colony-stimulating factor (GM-CSF) to form a high-affinity receptor for IL-3. The interleukin-3 receptor α chain (CD123) has been identified as a potential immunotherapeutic target because it is overexpressed in AML compared with normal hematopoietic stem cells. |
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