Product Description |
The Lgr5/GPR49 protein is a receptor for R-spondins that enhances the canonical Wnt signaling pathway and marks stem cells in the intestinal epithelium and hair follicles. Lgr5/GPR49 binds R-spondins (RSPO1-4), binds to phosphorylated LRP6 and Frizzled receptors, initiates Wnt signaling and amplifies target gene expression. Lgr5/GPR49 Protein, Human (HEK293, hFc) is the recombinant human-derived Lgr5/GPR49 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Lgr5/GPR49 Protein, Human (HEK293, hFc) is 522 a.a., with molecular weight of 110-120 kDa. |