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Mouse Fc gamma RIV / CD16-2 Protein, His Tag (MALS verified) Europäischer Partner

ArtNr FC4-M52H3-100ug
Hersteller ACROBiosystems
Menge 100 ug
Quantity options 100 ug 1 mg 50 ug
Kategorie
Typ Proteins Recombinant
Format Solid
Specific against Mouse (Murine, Mus musculus)
Host HEK293
Konjugat/Tag Unconjugated, HIS
Purity 90%
Citations (1) Hirano M, et al. 2007. Nat Immunol. 8(7):762-71. (2) Mancardi DA. 2008. J Clin Invest. 118(11):3738-50. (3) Nimmerjahn F. 2005. Immunity. 23(1):41-51.
NCBI NP_653142.2
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Alias Fc gamma RIV,CD16-2,Fcgr4
Versandbedingung Raumtemperatur
Lieferbar
Manufacturer - Category
Protein / MABSol® Fc Receptors
Manufacturer - Conjugate / Tag
C-10xHis, Unconjugated
Shipping Temperature
RT
Storage Conditions
-20°C
Molecular Weight
22.8 kDa
Manufacturer - Format
Powder
Description
Mouse CD16-2, His Tag (FC4-M52H3) is expressed from human 293 cells (HEK293). It contains AA Gly 21 - Gln 203 (Accession # A0A0B4J1G0-1).
Background
FcgR4(Low affinity immunoglobulin gamma Fc region receptor IV) is also known as CD16-2, FcgammaRIV, receptor for the Fc region of immunoglobulin gamma . Also acts as a receptor for the Fc region of immunoglobulin epsilon . Binds with intermediate affinity to both IgG2a and IgG2b . Does not display binding to IgG1 or IgG3. Plays a role in promoting bone resorption by enhancing osteoclast differentiation following binding to IgG2a. Binds with low affinity to both the a and b allotypes of IgE. Has also been shown to bind to IgE allotype a only but not to allotype b. Binding to IgE promotes macrophage-mediated phagocytosis, antigen presentation to T cells, production of proinflammatory cytokines and the late phase of cutaneous allergic reactions
Molecule
Fc gamma RIV / CD16-2
Exp Region
Gly 21 - Gln 203
Characteristics
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 22.8 kDa. The protein migrates as 30-38 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin
1.0 EU per μg
Buffer
PBS, pH7.4
Stability
● -20°C to -70°C for 12 months in lyophilized state;
● -70°C for 12 months under sterile conditions after reconstitution._x000D_For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Protectant
trehalose

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 100 ug
Lieferbar: In stock
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