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Recombinant Mouse Complement component receptor 1-like protein(Cr1l),partial

Recombinant Mouse Complement component receptor 1-like protein(Cr1l),partial

ArtNr	CSB-EP717575MO1-20
Hersteller	Cusabio
Menge	20ug
Quantity options	1mg 10ug 100ug 20ug 200ug 50ug 500ug
Kategorie	Peptides & Proteins Recombinant Proteins
Typ	Proteins Recombinant
Format	Liquid or Lyophilized powder
Specific against	Mouse
Purity	Greater than 85% as determined by SDS-PAGE.
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
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Research Areas	Others
Target / Protein	Cr1l
Biologically Active	Not Test
Expression System	E.coli
Species of origin	Mus musculus (Mouse)
Uniprot ID	Q64735
AA Sequence	ELRGGLGKHGHTVHREPAVNRLCADSKRWSGLPVS AQRPFPMGHCPAPSQLPSAKPINLTDESMFPIGTY LLYECLPGYIKRQFSITCKQDSTWTSAEDKCIRKQ CKTPSDPENGLVHVHTGIQFGSRINYTCNQGYRLI GSSSAVCVITDQSVDWDTEAPICEWIPCEIPPGIP NGDFFSSTREDFHYGMVVTYRCNTDARGKALFNLV GEPSLYCTSNDGEIGVWSGPPPQCIELNKCTPPPY VENAVMLSENRSLFSLRDIVEFRCHPGFIMKGASS VHCQSLNKWEPELPSCFKGVICRLPQEMSGFQKGL GMKKEYYYGENVTLECEDGYTLEGSSQSQCQSDGS WNPLLAKCVSRSISG
Tag Info	N-terminal 6xHis-tagged
Expression Region	41-405aa
Protein Length	Partial
MW	44.5 kDa
Alternative Name(s)	Complement regulatory protein Crry Protein p65
Relevance	Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. Also acts as a decay-accelerating factor, preventing the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade. Plays a crucial role in early embryonic development by maintaining fetomaternal tolerance. Also acts as a costimulatory factor for T-cells which favors IL-4 secretion.
Reference	The murine complement receptor gene family: III. The genomic and transcriptional complexity of the Crry and Crry-ps genes. Paul M.S., Aegerter-Shaw M., Cepek K., Miller M.D., Weis J.H. J. Immunol. 144:1988-1996(1990)
Purity	Greater than 85% as determined by SDS-PAGE.
Form	Liquid or Lyophilized powder
Buffer	If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Reconstitution	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20C/-80C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C.
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week.
Function	Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. Also acts as a decay-accelerating factor, preventing the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade. Plays a crucial role in early embryonic development by maintaining fetomaternal tolerance. Also acts as a costimulatory factor for T-cells which favors IL-4 secretion.
Subcellular Location	Membrane, Single-pass type I membrane protein
Protein Families	Receptors of complement activation (RCA) family
Tissue Specificity	Ubiquitously expressed (at protein level).
Tag Information	N-terminal 6xHis-tagged

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