ArtNr |
CD3-H5226-1mg |
Hersteller |
ACROBiosystems
|
Menge |
1 mg |
Kategorie |
|
Typ |
Proteins Recombinant |
Format |
Powder |
Specific against |
Human |
Host |
HEK293 |
Konjugat/Tag |
Unconjugated, HIS |
Purity |
95% |
Citations |
(1) Garnache-Ottou F., et al., 2005, Blood 105 (3): 1256-64. (2) Hernandez-Caselles T, et al., 2006, J. Leukoc. Biol. 79 (1): 46-58. (3) Walter RB, et al., 2007, Blood 109 (10): 4168-70. (4) Ulyanova, T. et al., 1999, Eur. J. Immunol. 29:3440. (5) Crocker, P.R. and A. Varki, 2001, Immunology 103:137. |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Alias |
CD33,SIGLEC3,gp67 |
Lieferbar |
|
Manufacturers Category |
Protein / Bio-Markers & CD Antigens |
Description |
Human Siglec-3, His Tag (CD3-H5226) is expressed from human 293 cells (HEK293). It contains AA Asp 18 - His 259 (Accession # AAH28152.1). |
Molecule |
Siglec-3 |
Exp Region |
Asp 18 - His 259 |
Storage |
-20℃ |
Shipping |
RT |
Stability |
-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution.
For long term storage, the product should be stored at lyophilized state at -20°C or lower. |
Molecular Weight |
27.6 kDa |
Characteristics |
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 27.6 kDa. The protein migrates as 43-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Endotoxin |
0.1 EU per μg |
Buffer |
PBS, pH7.4 |
Background |
Myeloid cell surface antigen CD33 is also known as SIGLEC3, Siglecs (sialic acid binding Iglike lectins) and GP67, is a single-pass type I membrane protein which belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. Human CD33 / Siglec-3 cDNA encodes a 364 amino acid (aa) polypeptide with a hydrophobic signal peptide, an N-terminal Ig-like V-type domain, one Ig-like C2-type domains, a transmembrane region and a cytoplasmic tail. CD33 / Siglec-3 usually considered myeloid-specific, but it can also be found on some lymphoid cells. In the immune response, CD33 / Siglec-3 may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. CD33 / Siglec-3 induces apoptosis in acute myeloid leukemia. |
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