ArtNr |
BM-RPC27695-20ug |
Hersteller |
Biomatik
|
Menge |
20ug |
Kategorie |
|
Typ |
Proteins |
Specific against |
other |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Lieferbar |
|
Protein Type |
Recombinant Protein |
Gene Name |
mtnN |
Alternative Names |
MTA/SAH nucleosidase; MTAN; 5'-deoxyadenosine nucleosidase; DOA nucleosidase; dAdo nucleosidase; 5'-methylthioadenosine nucleosidase; MTA nucleosidase; S-adenosylhomocysteine nucleosidase; AdoHcy nucleosidase; SAH nucleosidase; ; SRH nucleosidase |
Uniprot |
A7ZWA7 |
Expression Region |
1-232aa |
AA Sequence |
MKIGIIGAMEEEVTLLRDKIEKRQTISLGGCEIYTGQLNGTEVALLKSGIGKVAAALGATLLLEHCKPDVIINTGSAGGLAPTLKVGDIVVSDEARYHDADVTAFGYEYGQLPGCPAGFKADDKLIAAAEACIAELNLNAVRGLIVSGDAFINGSVGLAKIRHNFPQAIAVEMEATAIAHVCHNFNVPFVVVRAISDVADQQSHLSFDEFLAVAAKQSSLMVESLVQKLAHG |
Sequence Info |
Full Length |
Tag Info |
N-terminal 10xHis-tagged and C-terminal Myc-tagged |
Theoretical MW |
31.8 kDa |
Purity |
Greater than 85% as determined by SDS-PAGE. |
Storage Buffer |
If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0. |
Endotoxin Level |
Not Tested |
Shipping Condition |
Ice packs |
Storage |
Short term: -20°C; Long term: -80°C. Minimize freeze and thaw cycles. |
Expiry Date |
1 year |
Research Area |
Epigenetics and Nuclear Signaling |
Restriction |
For Research Use Only. Not for use in diagnostic procedures, drug use, or for administration to humans or animals. |
Relevance |
Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively. Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine. Thus, is required for in vivo function of the radical SAM enzymes biotin synthase and lipoic acid synthase, that are inhibited by 5'-deoxyadenosine accumulation. |
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