Hersteller |
ACROBiosystems
|
Kategorie |
|
Typ |
Proteins Recombinant |
Specific against |
Human |
Format |
Powder |
Menge |
1 mg |
Host |
HEK293 |
ArtNr |
B72-H5254-1mg |
Konjugat/Tag |
Unconjugated, Fc |
eClass 6.1 |
34160400 |
eClass 9.0 |
42020190 |
Lieferbar |
|
Alias |
ICOSLG,B7-H2,B7H2,B7RP-1,B7RP1,CD275,GL50,ICOS-L,ICOSL,LICOS,ICOS ligand |
Purity |
95% |
Manufacturers Category |
Protein / Immune Checkpoint Proteins |
Description |
Human B7-H2, Fc Tag (B72-H5254) is expressed from human 293 cells (HEK293). It contains AA Asp 19 - Ser 258 (Accession # O75144-1). |
Molecule |
B7-H2 |
Exp Region |
Asp 19 - Ser 258 |
Storage |
-20℃ |
Shipping |
RT |
Stability |
-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution.
For long term storage, the product should be stored at lyophilized state at -20°C or lower. |
Molecular Weight |
53.1 kDa |
Characteristics |
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 53.1 kDa. The protein migrates as 66-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Endotoxin |
1.0 EU per μg |
Buffer |
Tris with Glycine, Arginine and NaCl, pH7.5 |
Background |
ICOS ligand (ICOSLG) is also known as B7 homolog 2 (B7-H2), B7-related protein 1 (B7RP-1) and CD antigen CD275, which belongs to the immunoglobulin superfamily and BTN/MOG family. ICOSLG contains one Ig-like C2-type (immunoglobulin-like) domain and one Ig-like V-type (immunoglobulin-like) domain. Isoform 1 is widely expressed, while isoform 2 is detected only in lymph nodes, leukocytes and spleen. B7-H2 is ligand for the T-cell-specific cell surface receptor ICOS. B7-H2 acts as a costimulatory signal for T-cell proliferation and cytokine secretion and induces also B-cell proliferation and differentiation into plasma cells. B7-H2 could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function. |
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