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Cyclosporin-A

Cyclosporin-A

Hersteller	ProSpec
Kategorie	Peptides & Proteins Recombinant Proteins
Typ	Proteins
Specific against	other
Menge	1gram
ArtNr	pro-408-1gram
eClass 6.1	34160400
eClass 9.0	42020190
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Introduction	Cyclosporin A is a noncytotoxic, natural, 11 amino acid cyclic peptide used clinically as an immunosuppressant for the treatment of autoimmune and inflammatory disorders and to prevent organ rejection after transplantation. Cyclosporin acts chiefly by inhibiting T lymphocyte function, which is vital for the propagation of inflammation. Cyclosporin A does not suppress the activity of other hematopoietic cells, does not cause bone marrow suppression and has a rapid onset of action as opposed to other immunosuppressive agents. Nevertheless, Cyclosporin A -induced nephrotoxicity remains an important clinical problem, and oxidative stress has been implicated as a potential responsible mechanism.
Description	Cyclosporin is a cyclic polypeptide immunosuppressant agent consisting of 11 amino acids and having a molecular weight of 1202.64. It is produced as a metabolite by the fungus species Beauveria nlyea. Chemically, cyclosporin is designated as [R-[R, R-(E)]]-cyclic(L-alanyl-D- alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-3-hydroxy-N, 4-dimethyl-L-2-amino-6-octenoyl-L--amino-butyryl- N-methylglycyl-N- methyl-L-leucyl-L-valyl-N-methyl-L-leucyl). Molecular Formula: C₆₂H₁₁₁N₁₁O₁₂.
Source	Beauveria Nlyea.
Physical Appearance	Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation	The Cyclosporin-A was lyophilized from a concentrated (1mg/ml) solution with no additives.
Purity	Greater than 98.0% as determined by: (a) Analysis by RP-HPLC. (b) Mass Spectral Anaylsis {MALDI-TOF exhibits correct Mw}.
Usage	ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Storage	Lyophilized Cyclosporin A although stable at room temperature for 3 weeks, should be stored desiccated below -18C. Upon reconstitution Cyclosporin A should be stored at 4C between 2-7 days and for future use below -18C. Please prevent freeze-thaw cycles.

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pro-408-1gram-safety-datasheet.pdf