Recombinant Human Interleukin-17B

IL-17 family members are glycoproteins secreted as dimers which induce local cytokine production and recruit granulocytes to sites of inflammation. The IL-17 family is comprised of at least six pro-inflammatory cytokines that share a conserved cysteine-knot structure but diverge at the N-terminus. IL-17 is induced by IL-15 and IL-23, mostly in activated CD4+ T cells distinct from Th1 or Th2 cells. IL-17B binds the IL-17B receptor, but not the IL-17 receptor, it is most homologous with IL-17D, which is expressed by resting CD4+ T cells and CD19+ B cells. IL17B Diseases associated with IL17B include spondyloarthropathy, and neuronitis, and among its related super-pathways are Mucin expression in CF via IL-6, IL-17 signaling pathways and STAT3 Pathway.

Escherichia Coli.

Interleukin-17B was Lyophilized from a0.2um filtered concentrated solution in PBS, pH7.4, 0.05% Tween-20 and 3%Trehalose.

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The ED50 as determined by inducing IL-8 secretion of human HepG2 cells is less than 1.0ug/ml, corresponding to a specific activity of 1000 IU/mg.