Recombinant Human Interleukin-4

IL4 is a pleiotropic cytokine produced by activated T cells. IL4 is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. IL4, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Escherichia Coli.

Lyophilized from a0.2um filtered concentrated (1mg/ml) solution in PBS, pH 7.4.

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The ED50 as determined by the dose-dependant stimulation of TF-1 cells is 0.2 ng/ml, corresponding to a Specific Activity of 5, 000, 000 IU/mg.