Human Integrin alpha 4 beta 7 (ITGA4&ITGB7) Heterodimer Protein, His Tag&Tag Free (MALS verified)

Human ITGA4&ITGB7 Heterodimer Protein, His Tag&Tag Free (IT7-H52W5) is expressed from human 293 cells (HEK293). It contains AA Tyr 34 - Arg 620 & Glu 20 - Pro 521 (Accession # P13612-1 & P26010-1).

Tyr 34 - Arg 620 & Glu 20 - Pro 521

RT

59.5 kDa & 59.4 kDa

1.0 EU per μg

Integrin alpha 4 beta 7 is an integrin family adhesion receptor that shares subunits with alpha 4 beta 1 (VLA4) and the E-Cadherin receptor, alpha E beta 7 . Integrin alpha 4 beta 7, which is critical for homing to intestinal mucosa, is induced during T cell activation in Peyer’s patches or mesenteric lymph nodes.Its expression requires signals from local dendritic and stromal cells, including secreted retinoic acid. The HIV-1 envelope protein gp120 binds to the active form of Integrin alpha 4 beta 7, and this may or may not account for the concentration of HIV-1 virus in the gut-associated lymphoid tissue (GALT). Integrin alpha 4 beta 7 may also be involved in lymphocyte trafficking in acute intestinal graft vs. host disease (GVHD).