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Fas/CD95, Cynomolgus (HEK293) Europäischer Partner

ArtNr HY-P76330-10ug
Hersteller MedChem Express
Menge 10 ug
Quantity options 100 ug 10 ug 1 ea 2 ug 50 ug
Specific against other
Purity 95.0
Citations [1]Liu C, et al. Differential expression of human Fas mRNA species upon peripheral blood mononuclear cell activation. Biochem J. 1995 Sep 15;310 ( Pt 3)(Pt 3):957-63.<br/>[2]Screaton RA, et al. Fas-associated death domain protein interacts with methyl-CpG binding domain protein 4: a potential link between genome surveillance and apoptosis. Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5211-6.<br/>[3]Brenner B, et al. Fas/CD95/Apo-I activates the acidic sphingomyelinase via caspases. Cell Death Differ. 1998 Jan;5(1):29-37.<br/>[4]Lee SM, et al. Stimulation of Fas (CD95) induces production of pro-inflammatory mediators through ERK/JNK-dependent activation of NF-κB in THP-1 cells. Cell Immunol. 2011;271(1):157-62.
Smiles QVTDISSKGF ELRKIVTTIE TQNLEGLHHE GQFCRNPCPP GERKARDCTV NEDEPDCVPC QEGKEYTDKG HFSSKCRRCR LCDEGHGLEV EINCTRTQNT KCRCKPNFFC NSAVCEHCDP CTKCKHGIIE ECTLTSNTKC KEEDSRSD
Alias Fas/CD95 Protein, Cynomolgus (HEK293),Cynomolgus,HEK293
Lieferbar
Product Description
Fas receptor is a cell surface death receptor, can bind to Fas ligand to form death-inducing signaling complexes, such as Fas associated death domain proteins (FADD)[1][2]. Fas receptor participates in the caspase cascade and regulate the activation of JNK and p38-K downstream. It is also involved in the signaling cascade of ERK/JNK MAPKs, activating MAPK3/ERK1, MAPK8/JNK and NF-κB, which has been implicated in the pathogenesis of various malignant tumors and immune system diseases[3][4]. Macaca mulatta Fas receptor contain a death domain (228-312 a.a.) that plays a key role in regulating programmed death. Fas/CD95 Protein, Cynomolgus (HEK293) has a full length of 173 amino acids (M1-D173), produced in HEK293 cells with tag free.
StorageTemperature
Stored at -20°C for 2 years
Shipping
Blue Ice
MolecularWeight
Approximately 19-27 kDa due to the glycosylation.
Manufacturers Product type
Recombinant Proteins

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 10 ug
Lieferbar: In stock
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