ArtNr |
HY-N1724-50ug |
Hersteller |
MedChem Express
|
CAS-Nr. |
80890-47-7 |
Menge |
50 ug |
Quantity options |
100ug
1mg
25 ug
50 ug
|
Kategorie |
|
Typ |
Chemicals |
Specific against |
other |
Purity |
99.0 |
Formula |
C46H75NO14 |
Citations |
[3]Hines IN, et al. Impaired T cell-mediated hepatitis in peroxisome proliferator activated receptor alpha (PPARα)-deficient mice. Biol Res. 2018 Feb 15;51(1):5.<br/>[4]Woo JT, et al. Isolation, characterization and biological activities of concanamycins as inhibitors of lysosomal acidification. J Antibiot (Tokyo). 1992 Jul;45(7):1108-16.<br/>[5]Vaněk, Z., et al. Immunomodulators isolated from microorganisms. Folia Microbiol. 1991. 36:99–111. <br/>[1]Togashi K, et al. Concanamycin A, a vacuolar type H(+)-ATPase inhibitor, induces cell death in activated CD8(+) CTL. Cytotechnology. 1997 Nov;25(1-3):127-35.<br/>[2]Eswarappa SM, et al. Folimycin (concanamycin A) inhibits LPS-induced nitric oxide production and reduces surface localization of TLR4 in murine macrophages. Innate Immun. 2008 Feb;14(1):13-24. |
Smiles |
C[C@H]([C@@](C[C@H]1O[C@@](O[C@H](C)[C@H]2OC(N)=O)([H])C[C@H]2O)(O[C@H](/C=C/C)[C@H]1C)O)[C@H](O)[C@@H]([C@](OC(/C(OC)=C/C(C)=C/[C@H]([C@@H](O)[C@H]3CC)C)=O)([H])[C@H](/C=C/C=C(C[C@H]([C@@H]3O)C)/C)OC)C |
ECLASS 10.1 |
32160000 |
ECLASS 11.0 |
32160000 |
UNSPSC |
12000000 |
Alias |
Antibiotic X 4357B; Folimycin; X 4357B |
Lieferbar |
|
Product Description |
Concanamycin A (Folimycin; Antibiotic X 4357B) is a macrolide antibiotic, a vacuolar type H+-ATPase (V-ATPase) inhibitor. Concanamycin A is also an inhibitor of lysosomal acidification, can be used to T cell-mediated inflammation research[1]-[5]. |
StorageTemperature |
-20°C, 3 years (Powder) |
Shipping |
Blue Ice |
Manufacturers Applications |
Cancer-programmed cell death |
MolecularWeight |
866.09 |
Clinical Information |
No Development Reported |
Manufacturers Research Area |
Cancer; Infection; Inflammation/Immunology |
Solubility |
DMSO : ≥ 10 mg/mL|Methanol : 10 mg/mL (ultrasonic; warming) |
Target |
Antibiotic; Bacterial; Proton Pump |
Manufacturers Target |
Antibiotic; Bacterial; Proton Pump |
Isoform |
Macrolide |
Manufacturers Pathway |
Anti-infection; Membrane Transporter/Ion Channel |
Manufacturers Product type |
Natural Products |
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