ArtNr |
HY-17377-25mg |
Hersteller |
MedChem Express
|
CAS-Nr. |
599179-03-0 |
Menge |
25 mg |
Kategorie |
|
Typ |
Chemicals |
Specific against |
other |
Purity |
99.91 |
Formula |
C32H42F3N5O6 |
Citations |
[1]Tagat JR, et al. Piperazine-based CCR5 antagonists as HIV-1 inhibitors. IV. Discovery of 1-[(4,6-dimethyl-5-pyrimidinyl)carbonyl]- 4-[4-[2-methoxy-1(R)-4-(trifluoromethyl)phenyl]ethyl-3(S)-methyl-1-piperazinyl]- 4-methylpiperidine (Sch-417690/Sch-D), a potent, highly selective, and orally bioavailable CCR5 antagonist. J Med Chem. 2004 May 6;47(10):2405-8.<br>[2]Strizki JM, et al. Discovery and characterization of vicriviroc (SCH 417690), a CCR5 antagonist with potent activity against human immunodeficiency virus type 1. Antimicrob Agents Chemother. 2005 Dec;49(12):4911-9. |
Smiles |
CC1(N2C[C@H](C)N([C@H](C3=CC=C(C(F)(F)F)C=C3)COC)CC2)CCN(C(C4=C(C)N=CN=C4C)=O)CC1.O=C(O)/C=C\C(O)=O |
ECLASS 10.1 |
32160000 |
ECLASS 11.0 |
32160000 |
UNSPSC |
12000000 |
Alias |
SCH-417690 (maleate); SCH-D (maleate) |
Lieferbar |
|
Product Description |
Vicriviroc maleate (SCH-417690 maleate; SCH-D maleate) is a potent, selective, oral bioavailable and CNS penetrated antagonist of CCR5, with a Ki of 2.5 nM, and also inhibits HIV-1 in PBMC cells, with IC90s of 3.3 nM (JrFL), 2.8 nM (ADA-M), 1.8 nM (301657), 4.9 nM (JV1083) and 10 nM (RU 570). |
StorageTemperature |
4°C (Powder, sealed storage, away from moisture) |
Shipping |
Room Temperature |
Manufacturers Applications |
COVID-19-anti-virus |
MolecularWeight |
649.70 |
Clinical_Information |
Phase 3 |
Manufacturers Research_Area |
Infection; Endocrinology |
Solubility |
DMSO : 50 mg/mL (ultrasonic)|H2O : 25 mg/mL (ultrasonic; warming) |
Manufacturers Target |
CCR; HIV |
Isoform |
CCR5; HIV-1 |
Pathway |
Anti-infection; GPCR/G Protein; Immunology/Inflammation |
Manufacturers Product type |
Reference compound |
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