ArtNr |
HY-13564-25mg |
Hersteller |
MedChem Express
|
CAS-Nr. |
130370-60-4 |
Menge |
25 mg |
Kategorie |
|
Typ |
Chemicals |
Specific against |
other |
Purity |
98.92 |
Formula |
C23H31N3O4S2 |
Citations |
[1]Botos I, et al. Batimastat, a potent matrix mealloproteinase inhibitor, exhibits an unexpected mode of binding. Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):2749-54.<br>[2]Ricci S, et al. Inhibition of matrix metalloproteinases attenuates brain damage in experimental meningococcal meningitis. BMC Infect Dis. 2014 Dec 31;14:726.<br>[3]Yin Z, et al. Increased MMPs expression and decreased contraction in the rat myometrium during pregnancy and in response to prolonged stretch and sex hormones. Am J Physiol Endocrinol Metab. 2012 Jul 1;303(1):E55-70.<br>[4]Russo LA, et al. Regulated expression of matrix metalloproteinases, inflammatory mediators, and endometrial matrix remodeling by 17beta-estradiol in the immature rat uterus. Reprod Biol Endocrinol. 2009 Nov 4;7:124.<br>[5]Hansen HP, et al. Inhibition of metalloproteinases enhances the internalization of anti-CD30 antibody Ki-3 and the cytotoxic activity of Ki-3 immunotoxin. Int J Cancer. 2002 Mar 10;98(2):210-5.<br>[6]Giavazzi R, et al. Batimastat, a synthetic inhibitor of matrix metalloproteinases, potentiates the antitumor activity of cisplatin in ovarian carcinoma xenografts. Clin Cancer Res. 1998 Apr;4(4):985-92. |
Smiles |
O=C(N[C@@H](CC1=CC=CC=C1)C(NC)=O)[C@H](CC(C)C)[C@H](CSC2=CC=CS2)C(NO)=O |
ECLASS 5.1 |
32160000 |
ECLASS 6.1 |
32160000 |
ECLASS 8.0 |
32160000 |
ECLASS 9.0 |
32160000 |
ECLASS 10.0.1 |
32160000 |
ECLASS 10.1 |
32160000 |
ECLASS 11.0 |
32160000 |
UNSPSC |
12000000 |
Alias |
BB94 |
Lieferbar |
|
Product Description |
Batimastat is a potent broad spectrum MMP inhibitor with IC50 of 3, 4, 4, 6, and 20 nM for MMP-1, MMP-2, MMP-9, MMP-7 and MMP-3, respectively. |
StorageTemperature |
-20°C, 3 years; 4°C, 2 years (Powder) |
Shipping |
Room Temperature |
Manufacturers Applications |
Cancer-Kinase/protease |
MolecularWeight |
477.64 |
Clinical_Information |
No Development Reported |
Manufacturers Research_Area |
Cancer |
Solubility |
DMSO : 25 mg/mL (ultrasonic; warming; heat to 70°C) |
Manufacturers Target |
MMP |
Pathway |
Metabolic Enzyme/Protease |
Manufacturers Product type |
Reference compound |
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