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Mitoxantrone (diacetate)

Mitoxantrone (diacetate)

ArtNr	HY-13502B-1ea
Hersteller	MedChem Express
CAS-Nr.	70711-41-0
Menge	1 ea
Quantity options	100 mg 1 ea
Kategorie	Reagents & Chemicals Biochemicals
Typ	Chemicals
Specific against	other
Formula	C26H36N4O10
Citations	[1]Takeuchi N, et al. Inhibitory effect of mitoxantrone on activity of protein kinase C and growth of HL60 cells. J Biochem. 1992 Dec;112(6):762-7.<br/>[2]Bellosillo B, et al. Mitoxantrone, a topoisomerase II inhibitor, induces apoptosis of B-chronic lymphocytic leukaemia cells. Br J Haematol. 1998 Jan;100(1):142-6.<br/>[3]Vibet S, et al. Differential subcellular distribution of mitoxantrone in relation to chemosensitization in two human breast cancer cell lines. Drug Metab Dispos. 2007 May;35(5):822-8.<br/>[4]Fujimoto S, et al. Antitumor activity of mitoxantrone against murine experimental tumors: comparative analysis against various antitumor antibiotics. Cancer Chemother Pharmacol. 1982;8(2):157-62.<br/>[5]Sharon E Altmann, et al. Inhibition of cowpox virus and monkeypox virus infection by mitoxantrone. Antiviral Res. 2012 Feb;93(2):305-308.
Smiles	O=C1C2=C(C(NCCNCCO)=CC=C2NCCNCCO)C(C3=C(O)C=CC(O)=C13)=O.O=C(C)O.O=C(C)O
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Alias	Mitozantrone (diacetate); NSC 301739 (diacetate)
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Product Description	Mitoxantrone diacetate is a potent topoisomerase II inhibitor. Mitoxantrone diacetate also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 μM. Mitoxantrone diacetate induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone diacetate shows antitumor activity[1][2][3][4]. Mitoxantrone diacetate also has anti-orthopoxvirus activity with EC50s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively[5].
Shipping	Room temperature
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	564.58
Clinical Information	Launched
Manufacturers Research Area	Cancer; Infection
Solubility	10 mM in DMSO
Target	Apoptosis; Endogenous Metabolite; Orthopoxvirus; PKC; Topoisomerase
Manufacturers Target	Apoptosis; Endogenous Metabolite; Orthopoxvirus; PKC; Topoisomerase
Isoform	PKC; Topo II
Manufacturers Pathway	Anti-infection; Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease; TGF-beta/Smad
Manufacturers Product type	Reference compound

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