« Zurück
Home /
MCC950 (sodium)

MCC950 (sodium)

ArtNr	HY-12815A-25mg
Hersteller	MedChem Express
CAS-Nr.	256373-96-3
Menge	25 mg
Kategorie	Reagents & Chemicals Biochemicals
Typ	Chemicals
Specific against	other
Purity	99.61
Formula	C20H23N2NaO5S
Citations	Acta Biochim Biophys Sin (Shanghai). 2021 Sep 27;gmab137.<br>Acta Pharmacol Sin. 2021 Jul 5.<br>Aging (Albany NY). 2021 Aug 25;13(16):20534-20551.<br>Am J Physiol Gastrointest Liver Physiol. 2021 Mar 17.<br>Arch Med Sci. 2021 Mar.<br>Arch Oral Biol. 2021 Sep 30;131:105269.<br>Arch Oral Biol. 2023 Jan 28;147:105632.<br>Bioengineered. 2022 Mar;13(3):4810-4820.<br>bioRxiv. 2023 Jun 25.<br>bioRxiv. January 25, 2022.<br>Br J Pharmacol. 2021 Apr 26.<br>Brain Res. 2022: 148206.<br>Cancer Lett. 2021 Jan 28;497:178-189.<br>Cell Biol Toxicol. 2022 Feb 28;1-17.<br>Cell Cycle. 2021 Sep 8;1-14.<br>Cell Death Differ. 2022 Sep 14.<br>Cell Death Dis. 2021 Jan 12;12(1):78.<br>Cell Death Dis. 2022 Apr 19;13(4):372.<br>Cell Death Dis. 2022 Mar 29;13(3):281.<br>Cell Death Dis. 2022 Mar 30;13(3):283.<br>Cell Death Dis. 2023 Apr 21;14(4):282.<br>Cell Death Dis. 2023 Mar 1;14(3):174.<br>Cell Death Dis. 2018 Sep 20;9(10):946. <br>Cell Rep. 2023 Feb 16;42(2):112133.<br>Chemosphere. 2020 Mar;242:124959.<br>Clin Transl Med. 2022 Aug;12(8):e1002.<br>CNS Neurosci Ther. 2021 Dec 23.<br>Ecotoxicol Environ Saf. 2021 Aug 5;223:112590.<br>EMBO J. 2022 Oct 17;e111173.<br>EMBO Rep. 2022 Feb 3;23(2):e53499.<br>Environ Sci Pollut Res Int. 2023 Sep 23.<br>Environ Toxicol Pharmacol. 2022 Sep 28;103981.<br>Eur J Pharmacol. 2024 Mar 1:176428.<br>Exp Cell Res. 2021, 112634.<br>Exp Cell Res. 2022 Jun 15;418(1):113264.<br>Exp Eye Res. 2021 Jun 15;108668.<br>Exp Neurol. 2023 Oct 26:114586.<br>Exp Ther Med. 2021 Oct;22(4):1046.<br>Food Chem Toxicol. 2019 Mar;125:392-402.<br>Food Chem Toxicol. 2021 Jan;147:111867.<br>Front Cell Dev Biol. 18 June 2021.<br>Front Cell Dev Biol. 2021 Apr 8;9:643996.<br>Front Oncol. 24 September 2021.<br>Front Pharmacol. 08 November 2021.<br>Front Pharmacol. 2021 Jul 15;12:667644.<br>Heliyon. 2023 Nov, 9, 11, e21522.<br>Immunity. 2024 Feb 16:S1074-7613(24)00044-X.<br>Immunology. 2021 Apr 9.<br>Int Immunopharmacol. 2022 Oct 13;113(Pt A):109305.<br>Int Immunopharmacol. 2022 Oct 14;113(Pt A):109321.<br>Int Immunopharmacol. 2023 Aug 23;124(Pt A):110781.<br>Int Immunopharmacol. 2023 Feb 10;116:109828.<br>Int J Biol Sci. 2022 Jan 1;18(2):809-825.<br>Int J Cardiol. 2021 Jun 19;S0167-5273(21)00825-1.<br>Int J Med Sci. 2021 Jan 23;18(6):1382-1389.<br>Invest Ophthalmol Vis Sci. 2022 Jul 8;63(8):15.<br>J Agric Food Chem. 2021 Jun 30.<br>J Agric Food Chem. 2021 Nov 24.<br>J Allergy Clin Immunol. 2022 Mar 26;S0091-6749(22)00382-7.<br>J Dent Res. 2022 Jan 20;220345211059418.<br>J Funct Foods. 2023, 100: 105386.<br>J Hazard Mater. 2020 Nov 15;399:123034.<br>J Inflamm Res. 2021 Nov 2;14:5699-5711.<br>J Invest Dermatol. 2022 Apr 11;S0022-202X(22)00272-X.<br>J Microbiol. 2021 Jun 1.<br>J Neuroinflammation. 2021 Jun 24;18(1):142.<br>J Neuroinflammation. 2021 Oct 19;18(1):239.<br>J Neuroinflammation. 2022 Jun 21;19(1):163.<br>J Neuroinflammation. 2022 Jun 6;19(1):133.<br>J Transl Med. 2024 Feb 15;22(1):155.<br>Life Sci. 2021, 119466.<br>Life Sci. 2022 Aug 27;120905.<br>Microbiol Spectr. 2022 Mar 7;e0209721.<br>Microorganisms. 2021 Sep 17;9(9):1983.<br>Molecules. 2018 Feb 27;23(3). pii: E522. <br>Molecules. 2023 Apr 29, 28(9), 3817.<br>Neural Plast. 2018 Apr 24;2018:9163521. <br>Neurobiol Dis. 2018 Jun;114:24-30.<br>Neurobiol Dis. 2021 Oct 18;105534.<br>Neurochem Res. 2022 Mar 29.<br>Neuropsychopharmacol. 2021 Jun 29.<br>Oxid Med Cell Longev. 2021 Feb 26.<br>Oxid Med Cell Longev. 2022 Feb 7;2022:9030771.<br>Oxid Med Cell Longev. 2022 May 17;2022:4177317.<br>Parasit Vectors. 2022 Sep 23;15(1):334.<br>Pharmacol Res. 2022 Feb 24;106143.<br>Phytomedicine. 2023 Oct 21, 155159.<br>Poultry Sci. 2023 Feb 17.<br>PPAR Res. 26 Aug 2021.<br>Redox Biol. September 2022, 102404.<br>Research Square Preprint. 2021 Aug.<br>Research Square Preprint. 2021 Feb.<br>Research Square Preprint. 2021 Mar.<br>Research Square Preprint. 2022 Jan.<br>Research Square Preprint. 2022 Mar.<br>Research Square Preprint. 2022 May.<br>Research Square Print. 2022 Aug.<br>Research Square Print. 2022 Jun.<br>Research Square Print. 2022 May.<br>Research Square Print. September 15th, 2022.<br>Sci Immunol. 2022 Feb 4;7(68):eabk2092.<br>Sci Total Environ. 2023 Apr 13;163460.<br>Sci Transl Med. 2023 Jan 11;15(678):eabl7895.<br>SSRN. 2023 Dec 5.<br>SSRN. 8 Nov 2021.<br>Ther Adv Med Oncol. 2021 Jan 21.<br>Toxicology. 2019 Dec 1;428:152304.<br>Toxics. 2022, 10(6), 285.<br>Vet Microbiol. 2021, 109130.<br>Virulence. 2022 Dec;13(1):1486-1501.<br>ACS Nano. 2023 Nov 21.<br>Acta Pharmacol Sin. 2021 Aug 2.<br>Adv Sci (Weinh). 2024 Mar 14:e2305934.<br>Aging Cell. 2023 Mar 31;e13811.<br>Anat Rec. 2021 Feb;304(2):302-312.<br>Antioxidants (Basel). 2024 Jan 31;13(2):183.<br>Aquat Toxicol. https://pubmed.ncbi.nlm.nih.gov/38228041<br>Arch Biochem Biophys. 2023 Mar 4;109558.<br>Atherosclerosis. 2019 Oct;289:132-142.<br>Autophagy. 2020 Dec 19;1-16.<br>Basic Res Cardiol. 2022 Aug 23;117(1):40.<br>Bioact Mater. 2024 Apr, 34, Pages 37-50.<br>Biochem Biophys Res Commun. 2019 Jun 30;514(3):998-1003.<br>Biochem Biophys Res Commun. 2020 Apr.<br>Biochim Biophys Acta Mol Cell Biol Lipids. 2023 Nov 27:159428.<br>Biochim Biophys Acta Mol Cell Res. 2023 Oct 5:119603.<br>Biochim Biophys Acta Mol Cell Res. 2024 Feb 15:119689.<br>Biochim Biophys Acta. 2017 Feb 13;1863(6):1556-1567.<br>Biochim Biophys Acta. 2017 Oct 3;1864(1):1-10.<br>Biofactors. 2018 Mar;44(2):123-136.<br>Biomed Pharmacother. 2022 Jun 6;152:113229.<br>Biomed Pharmacother. 2023 Jan 11;159:114216.<br>Biomed Pharmacother. 2023 Jun 28;165:115047.<br>bioRxiv. 2023 Jul 7.<br>BMC Cardiovasc Disord. 2023 Sep 11;23(1):446.<br>Cell Commun Signal. 2023 May 25;21(1):123.<br>Cell Death Dis. 2017 Nov 16;8(11):e3170. <br>Cell Death Dis. 2020 May 15;11(5):377.<br>Cell Death Dis. 2023 Mar 17;14(3):200.<br>Cell Death Discov. 2022 Dec 29;8(1):500.<br>Cell Death Discov. 2024 Feb 20;10(1):91.<br>Cell Mol Immunol. 2020 Mar;17(3):283-299.<br>Cell Prolif. 2020 Dec 31;e12973.<br>Chem Biol Interact. 2023 May 9;110541.<br>Clin Exp Immunol. 2018 Nov;194(2):231-243. <br>Clin Exp Immunol. 2024 Mar 22:uxae028.<br>Clin Immunol. 2023 Mar 22;250:109300.<br>Dig Dis Sci. 2018 Jan;63(1):81-91.<br>Ecotoxicol Environ Saf. 2022 Dec 9;249:114359.<br>Eur J Pharmacol. 2022 Nov 3;175364.<br>Eur J Pharmacol. 2023 Nov 9:176182.<br>Evid Based Complement Alternat Med. 2018 Aug 26;2018:3571604. <br>Exp Biol Med. 2023 Sep 25:15353702231191124.<br>Exp Cell Res. 2019 Oct 1;383(1):111488.<br>Exp Ther Med. 2023 Feb 15.<br>Food Chem Toxicol. 2019 Mar;125:392-402.<br>Food Chem Toxicol. 2023 Jun 2;113870.<br>Food Chem Toxicol. 2023 Sep 23;114060.<br>Free Radic Biol Med. 2021 Jul 8;S0891-5849(21)00408-1.<br>Free Radic Biol Med. 2023 Mar 27;202:46-61.<br>Front Immunol. 2020 Jul 24;11:1863.<br>Front Pharmacol. 2020 Mar 31;11:200.<br>Front Pharmacol. 2022 Jul 5;13:906548.<br>Front Psychiatry. 2019 Jan 7;9:734.<br>Immunology. 2022 Apr 25.<br>Inflammopharmacology. 2020 Dec;28(6):1495-1508.<br>Int Immunol. 2023 Sep 26:dxad037.<br>Int Immunopharmacol. 2021 Jan 7;92:107352.<br>Int Immunopharmacol. 2022 Dec 9;114:109523.<br>Int Immunopharmacol. 2022 Jul 6;110:109012.<br>Int Immunopharmacol. 2023 Aug 11;123:110752.<br>Int Immunopharmacol. 2023 Jul 31;123:110657.<br>Int Immunopharmacol. 2024 Feb 17:130:111680.<br>Int J Biol Sci. 2023; 19(3):936-949.<br>Int J Mol Med. 2018 Aug;42(2):1086-1095.<br>Int J Mol Med. 2023 Apr;51(4):32.<br>Int J Mol Sci. 2022, 23(21), 13224.<br>Int J Mol Sci. 2023 Aug 11, 24(16), 12709.<br>Int J Mol Sci. 2023 Jul 20, 24(14), 11692.<br>Int J Mol Sci. 2023 Mar 27.<br>Int J Mol Sci. 2023 May 12, 24(10), 8684.<br>Int J Neuropsychopharmacol. 2021 Jan 20;24(1):64-76.<br>Invest Ophthalmol Vis Sci. 2023 Mar 1;64(3):16.<br>iScience. 2023 May 30.<br>J Adv Res. 2023 Mar 28;S2090-1232(23)00090-5.<br>J Agric Food Chem. 2023 Aug 30;71(34):12645-12656.<br>J Agric Food Chem. 2023 Jan 15.<br>J Agric Food Chem. 2023 May 4.<br>J Am Heart Assoc. 2017 Sep 4;6(9). pii: e006347.<br>J Cell Biochem. 2019 Apr;120(4):5160-5168.<br>J Control Release. 2021 Jan 10;329:445-453.<br>J Endocrinol. 2023 Feb 16;256(3):e220335.<br>J Ethnopharmacol. 2023 Jun 11;116777.<br>J Ethnopharmacol. 2023 Mar 2;116304.<br>J Ethnopharmacol. 2023 Nov 27:117490.<br>J Funct Foods. 2023 Feb.<br>J Funct Foods. 2023 Jun, 105, 105582.<br>J Funct Foods. December 2020, 104274.<br>J Hypertens. 2023 Oct 10.<br>J Inflamm Res. 2023 Feb 27.<br>J Neuroimmunol. 2021, 577543.<br>J Neuroinflammation. 2018 Mar 24;15(1):95. <br>J Neuroinflammation. 2020 Jul 23;17(1):219.<br>J Nutr Biochem. 2023 Sep 2;109436.<br>J Transl Med. 2023 Dec 11;21(1):904.<br>Journal of Traditional and Complementary Medicine. 2023 Mar 29.<br>Kaohsiung J Med Sci. 2022 Nov 21.<br>Life Sci. 2020 Jul 15;253:117747.<br>Life Sci. 2021 Jan 15;265:118833.<br>Mediators Inflamm. 2024 Jan 30.<br>Microbiol Immunol. 2023 Mar 18.<br>Mol Immunol. 2020 Jul;123:74-87.<br>Mol Med Rep. 2023 Sep 8.<br>Mol Neurobiol. 2023 Sep 13.<br>Molecules. 2022 May 4;27(9):2931.<br>Molecules. 2024 Feb 4;29(3):712.<br>Nat Commun. 2023 Feb 16;14(1):872.<br>Nat Commun. 2023 Jan 25;14(1):399.<br>Nat Immunol. 2022 Nov 28.<br>Nature. 2023 Dec;624(7991):442-450.<br>Naunyn Schmiedebergs Arch Pharmacol. 2020 Feb 18.<br>Neurobiol Dis. 2018 Feb 23;114:24-30.<br>Neurobiol Dis. 2018 Sep;117:15-27.<br>Oncol Lett. 2020 Nov;20(5):170.<br>Oxid Med Cell Longev. 2023 Feb 17.<br>Pflugers Arch. 2020 Nov;472(11):1577-1586.<br>Pharmacol Res. 2020 Dec 19;164:105384.<br>Phytomedicine. 2023 Jul 25, 116, 154909.<br>Phytomedicine. 2023 Nov 8, 155193.<br>Platelets. 2023 Dec;34(1):2156492.<br>PLoS One. 2020 Oct 1;15(10):e0239659.<br>Redox Biol. 2020 Jul;34:101523.<br>Research Square Preprint. 2020 Nov.<br>Research Square Preprint. 2023 Aug 7.<br>Research Square Preprint. 2023 Jul 19.<br>Research Square Preprint. 2023 May 24.<br>Research Square Preprint. 2023 May 30.<br>Research Square Preprint. 2024 Feb 1.<br>Research Square Preprint. 2024 Mar 15.<br>Sci Total Environ. 2023 Jun 13;164787.<br>Science. 2020 Dec 4;370(6521):eaay2002.<br>Small Structures. 2024 Feb 5.<br>Small. 2023 Oct 16:e2307448.<br>Toxins. 2023 May 29, 15(6), 366.<br>[1]Coll RC, et al. A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases. Nat Med. 2015 Mar;21(3):248-55.<br>[2]Zhai Y, et al. Inhibiting the NLRP3 Inflammasome Activation with MCC950 Ameliorates Diabetic Encephalopathy in db/db Mice. Molecules. 2018 Feb 27;23(3). pii: E522.
Smiles	O=S(C1=CC(C(C)(O)C)=CO1)([N-]C(NC2=C3CCCC3=CC4=C2CCC4)=O)=O.[Na+]
ECLASS 5.1	32160000
ECLASS 6.1	32160000
ECLASS 8.0	32160000
ECLASS 9.0	32160000
ECLASS 10.0.1	32160000
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Alias	CP-456773 sodium; CRID3 sodium salt
Lieferbar
Product Description	MCC950 sodium (CP-456773 sodium; CRID3 sodium salt) is a potent, selective NLRP3 inhibitor with IC50s of 7.5 and 8.1 nM in BMDMs and HMDMs, respectively.
StorageTemperature	4°C (Powder, sealed storage, away from moisture)
Shipping	Room Temperature
Manufacturers Applications	COVID-19-immunoregulation
MolecularWeight	426.46
Clinical_Information	No Development Reported
Manufacturers Research_Area	Inflammation/Immunology
Solubility	DMSO : 100 mg/mL (ultrasonic)\|H2O : ≥ 30 mg/mL
Manufacturers Target	NOD-like Receptor (NLR)
Isoform	NLRP3
Pathway	Immunology/Inflammation
Manufacturers Product type	Reference compound

Hinweis: Die dargestellten Informationen und Dokumente (Bedienungsanleitung, Produktdatenblatt, Sicherheitsdatenblatt und Analysezertifikat) entsprechen unserem letzten Update und sollten lediglich der Orientierung dienen. Wir übernehmen keine Garantie für die Aktualität. Für spezifische Anforderungen bitten wir Sie, uns eine Anfrage zu stellen.

Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Arbeitsanleitung (Data Sheet) anfordern

Produkdatenblatt anfordern

Sicherheitsdatenblatt anfordern

Einfache Bestellung Periodische Bestellung

Menge: 25 mg

lieferbar

Vergleichen

Auf den Wunschzettel

Weiterempfehlen per Mail

Angebot anfordern

Lieferzeit anfragen