ArtNr |
CX4-H52H9-100ug |
Hersteller |
ACROBiosystems
|
Menge |
100 ug |
Kategorie |
|
Typ |
Proteins Recombinant |
Format |
Powder |
Specific against |
Human |
Host |
HEK293 |
Konjugat/Tag |
Unconjugated, HIS |
Purity |
95% |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Alias |
PF4,CXCL4,MGC138298,SCYB4, C-X-C motif chemokine 4, Iroplact, Oncostatin-A |
Lieferbar |
|
Manufacturers Category |
Protein / Other Recombinant Proteins |
Description |
Human CXCL4, His Tag (CX4-H52H9) is expressed from human 293 cells (HEK293). It contains AA Glu 32 - Ser 101 (Accession # P02776-1). |
Molecule |
CXCL4 |
Exp Region |
Glu 32 - Ser 101 |
Storage |
-20℃ |
Shipping |
RT |
Stability |
-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution.
For long term storage, the product should be stored at lyophilized state at -20°C or lower. |
Molecular Weight |
9.7 kDa |
Characteristics |
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 9.7 kDa. The protein migrates as 13 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Endotoxin |
1.0 EU per μg |
Buffer |
10 mM Sodium Citrate, 150 mM NaCl, pH5.0 |
Background |
CXCL4, or Platelet factor 4 (PF4), is a small cytokine belonging to the CXC chemokine family. This chemokine is released from the alpha granules of activated platelets in the form of a homotetramer which has high affinity for heparin and is involved in platelet aggregation. CXCL4 is chemotactic for neutrophils and monocytes and also functions as an inhibitor of hematopoiesis, angiogenesis and T-cell function. CXCL4/PF4 is up-regulated in human liver fibrosis and that it plays a nonredundant, functional role in experimental liver fibrosis by mediating stellate cell proliferation, migration, and intrahepatic immune cell recruitment. |
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