ArtNr |
BOS-PROTP80188-5ug |
Hersteller |
Boster
|
Menge |
5ug |
Format |
Lyophilized Powder |
Specific against |
Human |
Dry ice |
Yes
|
Alias |
Neutrophil gelatinase-associated lipocalin; NGAL; p25; 25 kDa alpha-2-microglobulin-related subunit of MMP-9; Lipocalin-2; Oncogene 24p3; LCN2 |
Lieferbar |
|
Manufacturers Product Category |
Recombinant Proteins |
Short Description |
Neutrophil Gelatinase Associated Lipocalin Human Recombinant is expressed in Pichia pastoris having a molecular weight of approximately 21kDa. The LCN2 is purified by proprietary chromatographic techniques. |
Description |
Neutrophil Gelatinase Associated Lipocalin Human Recombinant is expressed in Pichia pastoris having a molecular weight of approximately 21kDa. The LCN2 is purified by proprietary chromatographic techniques. |
Gene Name |
LCN2 |
Contents |
LCN2 was lyophilized from 0.02M NH4HCO3. |
Purification |
Greater than 96% as determined by SDS-PAGE. |
Storage |
Lyophilized LCN2 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution LCN2 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. |
Reconstitution |
It is recommended to reconstitute the lyophilized LCN2 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions. |
Gene Full Name |
Neutrophil gelatinase-associated lipocalin |
Protein Function |
Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2, 5-dihydroxybenzoic acid (2, 5- DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth. |
Subcellular Localization |
Secreted |
Tissue Specificity |
Expressed in bone marrow and in tissues that are prone to exposure to microorganism. High expression is found in bone marrow as well as in uterus, prostate, salivary gland, stomach, appendix, colon, trachea and lung. Not found in the small intestine or peripheral blood leukocytes. |
Format Information |
Sterile Filtered White lyophilized (freeze-dried) powder. |
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