ArtNr |
BOS-PROTP28799-100ug |
Hersteller |
Boster
|
Menge |
100ug |
Format |
Lyophilized Powder |
Specific against |
Human |
Dry ice |
Yes
|
Alias |
GRN; PGRN; granulin; Acrogranin; propithelin; PC cell derived growth Factor; GEP; GP88; PEPI; PCDGF |
Lieferbar |
|
Manufacturers Product Category |
Recombinant Proteins |
Short Description |
Progranulin Human Recombinant produced in HEK is a single, glycosylated, polypeptide chain containing 1-593 amino acids and having a molecular mass of 74kDa. The Progranulin is purified by standard chromatographic techniques. |
Description |
Progranulin Human Recombinant produced in HEK is a single, glycosylated, polypeptide chain containing 1-593 amino acids and having a molecular mass of 74kDa. The Progranulin is purified by standard chromatographic techniques. |
Gene Name |
GRN |
Contents |
The protein contains 1xPBS. |
Bioactivity/Biological Activity |
Activates phospho-ERK1/2 in neuronal mouse P19 cells and regulates food intake and body weight. |
Purification |
Greater than 98.0% as determined by SDS-PAGE. |
Storage |
Lyophilized Progranulin although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution PGRN should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. |
Reconstitution |
It is recommended to reconstitute the lyophilized Progranulin in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions. |
Gene Full Name |
Granulins |
Protein Function |
Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling. |
Subcellular Localization |
Secreted. |
Tissue Specificity |
In myelogenous leukemic cell lines of promonocytic, promyelocytic, and proerythroid lineage, in fibroblasts, and very strongly in epithelial cell lines. Present in inflammatory cells and bone marrow. Highest levels in kidney. |
Format Information |
Sterile Filtered White lyophilized (freeze-dried) powder. |
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