Anti-AHNAK1 Purified Monoclonal Antibody

Boster Bio Anti-AHNAK1 Purified Monoclonal Antibody (Catalog# M05378). Tested in WB, IHC-F, ICC, IP application(s). This antibody reacts with Human, Mouse.

AHNAK1 (Desmoyokin) is a large (700 kDa) scaffold protein that translocates to the plasma membrane after an increas of extracellular calcium level or upon proteinkinase C activation and regulates extracellular calcium influx mediated by L-type Ca2+ channels. AHNAK1 has been implicated in diverse signal transduction proceses affecting cell differentiation and proliferation. In response to calcium-dependent intercellular contacts AHNAK1 forms multimeric complexes in the plasma membrane, connected with actin and annexin 2/S100A10 assemblies and is thus involved in organization of the plasma membrane architecture. In epithelial cells, AHNAK1 is localized in cytoplasm or is membrane-associated, but in cells of nonepithelial origin AHNAK1 is predominantly nuclear; it has a weak DNA-binding activity and associates with the DNA-ligase IV-XRCC4 complex.

Monoclonal

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Bacterially expressed fragment of N-terminal domain of human AHNAK1. The mouse monoclonal antibody EM-09 reacts with AHNAK1, a 700 kDa multi-functional adaptor protein expressed mainly in epithelial cell, various types of muscle cells and immune cells.

Store at 2-8°C. Do not freeze.

629101 MW

Nucleus.