ArtNr |
BOS-M05378 |
Hersteller |
Boster
|
Menge |
0.1mg |
Format |
Liquid |
Applikationen |
WB, IP, ICC, IHC-F |
Clon |
EM-09 |
Specific against |
Human, Mouse |
Host |
Mouse |
Isotype |
IgG1 |
Alias |
Desmoyokin |
Lieferbar |
|
Manufacturers Product Category |
Primary Antibodies, Monoclonal Antibodies |
Short Description |
Boster Bio Anti-AHNAK1 Purified Monoclonal Antibody (Catalog# M05378). Tested in WB, IHC-F, ICC, IP application(s). This antibody reacts with Human, Mouse. |
Description |
Boster Bio Anti-AHNAK1 Purified Monoclonal Antibody (Catalog# M05378). Tested in WB, IHC-F, ICC, IP application(s). This antibody reacts with Human, Mouse. |
Background |
AHNAK1 (Desmoyokin) is a large (700 kDa) scaffold protein that translocates to the plasma membrane after an increas of extracellular calcium level or upon proteinkinase C activation and regulates extracellular calcium influx mediated by L-type Ca2+ channels. AHNAK1 has been implicated in diverse signal transduction proceses affecting cell differentiation and proliferation. In response to calcium-dependent intercellular contacts AHNAK1 forms multimeric complexes in the plasma membrane, connected with actin and annexin 2/S100A10 assemblies and is thus involved in organization of the plasma membrane architecture. In epithelial cells, AHNAK1 is localized in cytoplasm or is membrane-associated, but in cells of nonepithelial origin AHNAK1 is predominantly nuclear; it has a weak DNA-binding activity and associates with the DNA-ligase IV-XRCC4 complex. |
Gene Name |
AHNAK1 |
Clonality |
Monoclonal |
Concentration |
1 mg/ml |
Contents |
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide |
Application Details |
Immunocytochemistry: Positive control: HeLa human cervix carcinoma cell line, permeabilization is required. Western blotting: Positive control: HeLa human cervix carcinoma cell line. |
Immunogen |
Bacterially expressed fragment of N-terminal domain of human AHNAK1. The mouse monoclonal antibody EM-09 reacts with AHNAK1, a 700 kDa multi-functional adaptor protein expressed mainly in epithelial cell, various types of muscle cells and immune cells. |
Purification |
Purified by protein-A affinity chromatography. |
Storage |
Store at 2-8°C. Do not freeze. |
Gene Full Name |
AHNAK1 nucleoprotein |
Molecular Weight |
629101 MW |
Protein Function |
May be required for neuronal cell differentiation. |
Subcellular Localization |
Nucleus. |
Protein Name |
Neuroblast differentiation-associated protein AHNAK |
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