ArtNr |
BOS-M00178-3 |
Hersteller |
Boster
|
Menge |
0.1mg |
Format |
Liquid |
Applikationen |
WB, IF, ELISA, IHC-P |
Clon |
7A11B1 |
Specific against |
Human, Mouse, Rat |
Host |
Mouse |
Isotype |
IgG1 |
Alias |
PD1, PD-1, CD279, SLEB2, hPD-1, hPD-l, hSLE1 |
Lieferbar |
|
Manufacturers Product Category |
Primary Antibodies, Monoclonal Antibodies |
Manufacturers Research Category |
Apoptosis |
Short Description |
Boster Bio Anti-PD-1 Pdcd1 Monoclonal Antibody [7A11B1] (Catalog # M00178-3). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat. |
Description |
Boster Bio Anti-PD-1 Pdcd1 Monoclonal Antibody [7A11B1] (Catalog # M00178-3). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat. |
Background |
Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antig en-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of "danger signals" such as LPS or other molecules associated with bacteria or other pathogens. Evidence for this is seen in PD1-null mice who exhibit hyperactivated immune systems and autoimmune diseases. Despite its predicted molecular weight, PD-1 often migrates at higher molecular weight in SDS-PAGE. |
Gene Name |
PDCD1 |
Clonality |
Monoclonal |
Concentration |
1 mg/mL |
Contents |
PD-1 Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide. |
Application Details |
PD-1 antibody can be used for detection of PD-1 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL. Antibody validated: Western Blot in mouse samples; Immunohistochemistry in human and mouse samples and Immunofluorescence in human and mouse samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher. |
Immunogen |
A ~150 amino acid recombinant protein from near the amino terminus of mouse PD-1. |
Purification |
PD-1 Monoclonal Antibody is Protein A purified. |
Storage |
PD-1 monoclonal antibody can be stored at -20°C, stable for one year. |
Gene Full Name |
Programmed cell death 1 |
Molecular Weight |
31842 MW |
Protein Function |
Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen- specific manner. Possible cell death inducer, in association with other factors (By similarity).. |
Subcellular Localization |
Membrane; Single-pass type I membrane protein. |
Tissue Specificity |
Thymus. |
Protein Name |
Programmed cell death 1 |
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