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Anti-Hu CD28 Purified Monoclonal Antibody

Anti-Hu CD28 Purified Monoclonal Antibody

ArtNr	BOS-M00065
Hersteller	Boster
Menge	0.1mg
Format	Liquid
Applikationen	WB, FC, IP, ICC, IHC-F
Clon	CD28.2
Specific against	Human, Primate
Host	Mouse
Isotype	IgG1 Kappa
Alias	TP44
Lieferbar
Manufacturers Product Category	Primary Antibodies, Monoclonal Antibodies
Short Description	Boster Bio Anti-Hu CD28 Purified Monoclonal Antibody (Catalog# M00065). Tested in Flow Cytometry, IP, WB, IHC-F, ICC application(s). This antibody reacts with Primate, Human.
Description	Boster Bio Anti-Hu CD28 Purified Monoclonal Antibody (Catalog# M00065). Tested in Flow Cytometry, IP, WB, IHC-F, ICC application(s). This antibody reacts with Primate, Human.
Background	CD28 is the critical T cell costimulatory receptor which provides to the cell the important second activation signal by binding CD80 and CD86 that are expressed by antigen presenting cells. Besides its costimulation role CD28 functions in preventing T cells from anergic hyporesponsive state or from undergoing premature apoptotic cell death. CD28 is also expressed on human fetal NK cells and some NK cell lines, whereas on murine NK cells the CD28 expression is much broader.
Gene Name	CD28
Clonality	Monoclonal
Concentration	1 mg/ml
Contents	Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Application Details	Flow cytometry: 1-12 µg/ml
Immunogen	DC28.1.3.3 murine T cell hybridoma transfected with human CD28 cDNA. The mouse monoclonal antibody CD28.2 recognizes an extracellular epitope of CD28, a disulfide-linked homodimeric type I glycoprotein (monomer of Mw 44 kDa) which is a critical costimulatory receptor of T cells.
Purification	Purified by protein-A affinity chromatography.
Storage	Store at 2-8°C. Do not freeze.
Gene Full Name	CD28 molecule
Molecular Weight	25066 MW
Protein Function	Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation (PubMed:8617933). Isoform 3 enhances CD40L-mediated activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells (PubMed:15067037).
Subcellular Localization	Membrane; Single-pass type I membrane protein.
Tissue Specificity	Expressed in T-cells and plasma cells, but not in less mature B-cells.
Protein Name	T-cell-specific surface glycoprotein CD28

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Menge: 0.1mg

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Lieferung vsl. bis 13.09.2024

Express-Lieferung: 10 Tage sparen

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