ArtNr |
BOS-FC04065-FITC-100tests |
Hersteller |
Boster
|
Menge |
100 tests |
Format |
Liquid |
Applikationen |
FC |
Clon |
FR4D11 |
Specific against |
Human |
Host |
Mouse |
Isotype |
IgG1 Kappa |
Konjugat/Tag |
FITC |
Sensitivity |
5ul per sample |
Alias |
Neprilysin;3.4.24.11 ;Atriopeptidase;Common acute lymphocytic leukemia antigen;CALLA;Enkephalinase;Neutral endopeptidase 24.11;NEP;Neutral endopeptidase;Skin fibroblast elastase;SFE;CD10;MME;EPN; |
Lieferbar |
|
Manufacturers Product Category |
Primary Antibodies, Monoclonal Antibodies |
Manufacturers Research Category |
Angiogenesis, Atherosclerosis, Cancer, Cardiovascular, Cytoskeleton/ECM, ECM Enzymes, Extracellular Matrix, Invasion/Microenvironment, Signal Transduction, Tumor Biomarkers |
Short Description |
Boster Bio Anti-human CD10 MME Monoclonal Antibody FITC Conjugated, Flow Validated (Catalog# FC04065-FITC). Tested in Flow Cytometry application(s). This antibody reacts with Human. |
Description |
Boster Bio Anti-human CD10 MME Monoclonal Antibody FITC Conjugated, Flow Validated (Catalog# FC04065-FITC). Tested in Flow Cytometry application(s). This antibody reacts with Human. |
Background |
CD10, also known as membrane metallo-endopeptidase, neutral endopeptidase (NEP), Neprilysin, or common acute lymphoblastic leukemia antigen (CALLA), is a zinc-dependent metalloprotease enzyme that degrades a number of small secreted peptides, most notably theamyloid beta peptide whose abnormal misfolding and aggregation in neural tissue has been implicated as a cause of Alzheimer's disease. This gene is localized to human chromosome 3 by study of somatic cell hybrids and regionalized the location to 3q21-q27 by in situ hybridization. By cDNA transfection analysis, CD10 is confirmed as a functional neutral endopeptidase of the type that has previously been called enkephalinase. CD10 has also been called atriopeptidase. Atriopeptidase specifically degrades atrial natriuretic factor. A specific enzyme inhibitor was developed and reported that it had effects similar to those of low-dose ANF infusion. These effects include diuresis, natriuresis, vasodilatation, and suppression of the renin-angiotensin-aldosterone system. |
Gene Name |
MME |
Clonality |
Monoclonal |
Concentration |
0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure. |
Contents |
PBS pH 7.2, 0.2% (w/v) BSA, 0.09% (w/v) sodium azide |
Application Details |
Flow Cytometry, 5μl is enough to stain 1 million PBMCs or 100μl whole blood sample |
Immunogen |
Raji cells |
Purification |
Protein A purified |
Storage |
Store at 2-8°C. Avoid repeated freeze-thaw cycles. |
Gene Full Name |
Neprilysin |
Molecular Weight |
85514 MW |
Protein Function |
Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids (PubMed:15283675, PubMed:8168535). Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond (PubMed:17101991). Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9 (PubMed:15283675). Involved in the degradation of atrial natriuretic factor (ANF) (PubMed:2531377, PubMed:2972276). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers (PubMed:20876573).. |
Subcellular Localization |
Cell membrane; Single-pass type II membrane protein. |
Protein Name |
Neprilysin |
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