ArtNr |
BOS-FC00137-mFluor540-200tests |
Hersteller |
Boster
|
Menge |
200 tests |
Format |
Liquid |
Applikationen |
FC |
Clon |
26ic |
Specific against |
Human, Monkey, Rhesus macaque |
Host |
Mouse |
Isotype |
IgG2b Kappa |
Konjugat/Tag |
mFLuor 540 |
Alias |
Monocyte differentiation antigen CD14 ;Myeloid cell-specific leucine-rich glycoprotein;CD14;Monocyte differentiation antigen CD14, urinary form;Monocyte differentiation antigen CD14, membrane-bound form;CD14; |
Lieferbar |
|
Manufacturers Product Category |
Primary Antibodies, Monoclonal Antibodies |
Manufacturers Research Category |
Cell Type Markers, Hematopoietic Progenitors, Immunology, Innate Immunity, Mesenchymal Stem Cells, Myeloid, Stem Cells, TLR Signaling |
Short Description |
Boster Bio Anti-Human CD14 Monoclonal Antibody mFluor540 Conjugated, Flow Validated (Catalog# FC00137-mFluor540). Tested in Flow Cytometry application(s). This antibody reacts with Human, Rhesus monkey, Cynomolgus monkey, Baboon. |
Description |
Boster Bio Anti-Human CD14 Monoclonal Antibody mFluor540 Conjugated, Flow Validated (Catalog# FC00137-mFluor540). Tested in Flow Cytometry application(s). This antibody reacts with Human, Rhesus monkey, Cynomolgus monkey, Baboon. |
Gene Name |
CD14 |
Clonality |
Monoclonal |
Concentration |
0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure. |
Contents |
PBS pH 7.2, 0.2% (w/v) BSA, 0.09% (w/v) sodium azide |
Application Details |
User needs to optimize the dilution ratio for this antibody. |
Immunogen |
Cultured human peripheral blood monocytes |
Purification |
Affinity column chromatography |
Storage |
Store at 2-8°C. Avoid repeated freeze-thaw cycles. |
Gene Full Name |
Monocyte differentiation antigen CD14 |
Molecular Weight |
40076 MW |
Protein Function |
Coreceptor for bacterial lipopolysaccharide (PubMed:1698311, PubMed:23264655). In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS) (PubMed:20133493, PubMed:23264655). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:8612135). Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway (PubMed:16880211). Binds electronegative LDL (LDL (-)) and mediates the cytokine release induced by LDL (-) (PubMed:23880187).. |
Subcellular Localization |
Cell membrane; Lipid- anchor, GPI-anchor. Secreted. Membrane raft. Golgi apparatus. Secreted forms may arise by cleavage of the GPI anchor. |
Tissue Specificity |
Detected on macrophages (at protein level) (PubMed:1698311). Expressed strongly on the surface of monocytes and weakly on the surface of granulocytes; also expressed by most tissue macrophages. |
Format Information |
Liquid, in PBS, pH7.2, <0.09% NaN3 and 0.2% (w/v) BSA |
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