ArtNr |
BOS-A14892 |
Hersteller |
Boster
|
Menge |
0.1mg |
Format |
Liquid |
Applikationen |
WB, IF, ELISA, IHC-P |
Specific against |
Human, Mouse |
Host |
Rabbit |
Isotype |
IgG |
Alias |
TASSC, HSPC299, NIPSNAP4, Protein NipSnap homolog 3A, Protein NipSnap homolog 4, NipSnap3A |
Lieferbar |
|
Manufacturers Product Category |
Primary Antibodies |
Manufacturers Research Category |
Neuroscience |
Short Description |
Boster Bio Anti-Protein NipSnap homolog 3A NIPSNAP3A Antibody (Catalog # A14892). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse. |
Description |
Boster Bio Anti-Protein NipSnap homolog 3A NIPSNAP3A Antibody (Catalog # A14892). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse. |
Background |
The NIPSNAP proteins comprise a family of evolutionarily well-conserved proteins with strong sequence similarity to the central portion of a protein encoded by C. elegans chromosome III between a 4-nitrophenylphosphatase (NIP) domain and non-neuronal SNAP25-like protein. NIPSNAP2, a novel gene encoding a protein with tyrosine phosphorylation sites and a transmembrane domain, is co-amplified with EGFR in approximately 40% of glioblastomas, the most common and malignant form of central nervous system tumors. While NIPSNAP3B is highly expressed skeletal muscle, NIPSNAP3A mRNA levels are low. NIPSNAP3A protein is associated with plasma membrane and partially localized in rafts. NIPSNAP proteins have been suggested to be important in vesicular transport. |
Gene Name |
NIPSNAP3A |
Clonality |
Polyclonal |
Concentration |
1 mg/mL |
Contents |
NIPSNAP3A Antibody is supplied in PBS containing 0.02% sodium azide. |
Application Details |
NIPSNAP3A antibody can be used for detection of NIPSNAP3A by Western blot at 0.5 - 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL. Antibody validated: Western Blot in mouse samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher. |
Immunogen |
NIPSNAP3A antibody was raised against a 16 amino acid synthetic peptide near the center of human NIPSNAP3A. The immunogen is located within amino acids 40 - 90 of NIPSNAP3A. |
Cross-reactivity |
At least two isoforms of NIPSNAP3A are known to exist. NIPSNAP3A antibody is predicted to not cross-react with any other members of the NIPSNAP protein family. |
Purification |
NIPSNAP3A Antibody is affinity chromatography purified via peptide column. |
Storage |
NIPSNAP3A antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
Gene Full Name |
Nipsnap homolog 3A (C. elegans) |
Molecular Weight |
28467 MW |
Protein Function |
Component of the GPI-GlcNAc transferase (GPI-GnT) complex in the endoplasmic reticulum, a complex that catalyzes transfer of GlcNAc from UDP-GlcNAc to an acceptor phosphatidylinositol, the first step in the production of GPI- anchors for cell surface proteins. May act by regulating the catalytic subunit PIGA. |
Subcellular Localization |
Cytoplasm, cytosol |
Tissue Specificity |
Ubiquitous. Highly expressed in liver, kidney and muscle. Expressed at intermediate level in brain, heart, colon, thymus, kidney, small intestine, placenta, lung, leukocytes and spleen. |
Protein Name |
Nipsnap homolog 3A (C. elegans) |
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