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Anti-XK-related protein 8 XKR8 Antibody

Anti-XK-related protein 8 XKR8 Antibody

ArtNr	BOS-A12134
Hersteller	Boster
Menge	0.1mg
Format	Liquid
Applikationen	WB, IF, ELISA, IHC-P
Specific against	Human
Host	Rabbit
Isotype	IgG
Alias	XRG8, hXkr8, XRG8, XK-related protein 8
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Manufacturers Product Category	Primary Antibodies
Manufacturers Research Category	Apoptosis
Short Description	Boster Bio Anti-XK-related protein 8 XKR8 Antibody (Catalog # A12134). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human.
Description	Boster Bio Anti-XK-related protein 8 XKR8 Antibody (Catalog # A12134). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human.
Background	The XK Kell blood group complex subunit-related family member 8 (XKR8) is a member of a family of proteins that promote the phagocytosis of dying cells by altering the phospholipid distribution of the plasma membrane (1). XKR8 is thought to be a “scramblase”, an enzyme that eliminates the asymmetry of phospholipid distribution in the plasma membrane. In apoptotic cells, XKR8 promotes the cell-surface exposure of phosphatidylserine (PtdSer) which serves as a signal for phagocytosis (1, 2).
Gene Name	XKR8
Clonality	Polyclonal
Concentration	1 mg/mL
Contents	XKR8 antibody is supplied in PBS containing 0.02% sodium azide.
Application Details	XKR8 antibody can be used for detection of XKR8 by Western blot at 1 - 2 μg/ml. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL. Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Immunogen	XKR8 antibody was raised against a 15 amino acid peptide near the carboxy terminus of human XKR8. The immunogen is located within the last 50 amino acids of XKR8.
Cross-reactivity	XKR8 antibody is human reactive. At least two isoforms are known to exist; this antibody will detect both isoforms.
Purification	XKR8 antibody is affinity chromatography purified via peptide column.
Storage	XKR8 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Gene Full Name	XK, Kell blood group complex subunit-related family, member 8
Molecular Weight	44655 MW
Protein Function	Promotes phosphatidylserine exposure on apoptotic cell surface, possibly by mediating phospholipid scrambling. Phosphatidylserine is a specific marker only present at the surface of apoptotic cells and acts as a specific signal for engulfment. Has no effect on calcium-induced exposure of phosphatidylserine. Activated upon caspase cleavage, suggesting that it does not act prior the onset of apoptosis.
Subcellular Localization	Cell membrane
Protein Name	XK, Kell blood group complex subunit-related family, member 8

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Menge: 0.1mg

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Lieferung vsl. bis 13.09.2024

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