ArtNr |
BOS-A10682 |
Hersteller |
Boster
|
Menge |
0.1mg |
Format |
Liquid |
Applikationen |
WB, ELISA |
Specific against |
Human |
Host |
Rabbit |
Isotype |
IgG |
Alias |
NgR2, NGRH1, NGRL3, Reticulon-4 receptor-like 2, Nogo receptor-like 3, NgR2 |
Lieferbar |
|
Manufacturers Product Category |
Primary Antibodies |
Manufacturers Research Category |
Neuroscience |
Short Description |
Boster Bio Anti-Reticulon-4 receptor-like 2 RTN4RL2 Antibody (Catalog # A10682). Tested in ELISA, WB applications. This antibody reacts with Human. |
Description |
Boster Bio Anti-Reticulon-4 receptor-like 2 RTN4RL2 Antibody (Catalog # A10682). Tested in ELISA, WB applications. This antibody reacts with Human. |
Background |
Reticulon 4 receptor-like 2 (RTN4RL2), also known as NgR2and NgRH1, is a 60 kDa glycosylphosphatidylinositol-anchored protein that is expressed primarily in the brain. It contains eight leucine-rich repeats that are flanked by cysteine-rich sequences at both the N- and C-termini. The membrane anchored RTN4RL2 can be solubilized through the action of phospholipase or an unidentified MTMMP to generate a 46 kDa soluble receptor. It has been suggested that RTN4RL2 may play a role in regulating axonal regeneration and plasticity in the adult central nervous system. |
Gene Name |
RTN4RL2 |
Clonality |
Polyclonal |
Concentration |
1 mg/mL |
Contents |
RTN4RL2 Antibody is supplied in PBS containing 0.02% sodium azide. |
Predicted Reactivity |
Rat, Mouse |
Application Details |
RTN4RL2 antibody can be used for detection of RTN4RL2 by Western blot at 1 - 2 μg/mL. Antibody validated: Western Blot in rat samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher. |
Immunogen |
Rabbit polyclonal RTN4RL2 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human RTN4RL2. The immunogen is located within amino acids 330 - 380 of RTN4RL2. |
Cross-reactivity |
Three alternatively spliced transcript variants have been observed. RTN4RL2 antibody is predicted to not cross-react with other Nogo receptor-like proteins. |
Purification |
RTN4RL2 Antibody is affinity chromatography purified via peptide column. |
Storage |
RTN4RL2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. |
Gene Full Name |
Reticulon 4 receptor-like 2 |
Molecular Weight |
46106 MW |
Protein Function |
Cell surface receptor that plays a functionally redundant role in the inhibition of neurite outgrowth mediated by MAG (By similarity). Plays a functionally redundant role in postnatal brain development. Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum. Does not seem to play a significant role in regulating axon regeneration in the adult central nervous system. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated by MAG (By similarity). Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:22325200). Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:22325200). |
Subcellular Localization |
Cell membrane |
Tissue Specificity |
Highly expressed in brain and liver. Expressed at lower levels in kidney, mammary gland, placenta, skeletal muscle, spleen and thyroid. |
Protein Name |
Reticulon 4 receptor-like 2 |
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