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Anti-Reticulon-4 receptor-like 2 RTN4RL2 Antibody

Anti-Reticulon-4 receptor-like 2 RTN4RL2 Antibody

ArtNr	BOS-A10682
Hersteller	Boster
Menge	0.1mg
Format	Liquid
Applikationen	WB, ELISA
Specific against	Human
Host	Rabbit
Isotype	IgG
Alias	NgR2, NGRH1, NGRL3, Reticulon-4 receptor-like 2, Nogo receptor-like 3, NgR2
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Manufacturers Product Category	Primary Antibodies
Manufacturers Research Category	Neuroscience
Short Description	Boster Bio Anti-Reticulon-4 receptor-like 2 RTN4RL2 Antibody (Catalog # A10682). Tested in ELISA, WB applications. This antibody reacts with Human.
Description	Boster Bio Anti-Reticulon-4 receptor-like 2 RTN4RL2 Antibody (Catalog # A10682). Tested in ELISA, WB applications. This antibody reacts with Human.
Background	Reticulon 4 receptor-like 2 (RTN4RL2), also known as NgR2and NgRH1, is a 60 kDa glycosylphosphatidylinositol-anchored protein that is expressed primarily in the brain. It contains eight leucine-rich repeats that are flanked by cysteine-rich sequences at both the N- and C-termini. The membrane anchored RTN4RL2 can be solubilized through the action of phospholipase or an unidentified MTMMP to generate a 46 kDa soluble receptor. It has been suggested that RTN4RL2 may play a role in regulating axonal regeneration and plasticity in the adult central nervous system.
Gene Name	RTN4RL2
Clonality	Polyclonal
Concentration	1 mg/mL
Contents	RTN4RL2 Antibody is supplied in PBS containing 0.02% sodium azide.
Predicted Reactivity	Rat, Mouse
Application Details	RTN4RL2 antibody can be used for detection of RTN4RL2 by Western blot at 1 - 2 μg/mL. Antibody validated: Western Blot in rat samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Immunogen	Rabbit polyclonal RTN4RL2 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human RTN4RL2. The immunogen is located within amino acids 330 - 380 of RTN4RL2.
Cross-reactivity	Three alternatively spliced transcript variants have been observed. RTN4RL2 antibody is predicted to not cross-react with other Nogo receptor-like proteins.
Purification	RTN4RL2 Antibody is affinity chromatography purified via peptide column.
Storage	RTN4RL2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Gene Full Name	Reticulon 4 receptor-like 2
Molecular Weight	46106 MW
Protein Function	Cell surface receptor that plays a functionally redundant role in the inhibition of neurite outgrowth mediated by MAG (By similarity). Plays a functionally redundant role in postnatal brain development. Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum. Does not seem to play a significant role in regulating axon regeneration in the adult central nervous system. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated by MAG (By similarity). Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:22325200). Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:22325200).
Subcellular Localization	Cell membrane
Tissue Specificity	Highly expressed in brain and liver. Expressed at lower levels in kidney, mammary gland, placenta, skeletal muscle, spleen and thyroid.
Protein Name	Reticulon 4 receptor-like 2

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Menge: 0.1mg

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Lieferung vsl. bis 04.10.2024

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