ArtNr |
BOS-A09965 |
Hersteller |
Boster
|
Menge |
0.1mg |
Format |
Liquid |
Applikationen |
WB, ELISA |
Specific against |
Human |
Host |
Rabbit |
Isotype |
IgG |
Alias |
CHCM1, PPP1R23, CHCM1, Coiled-coil-helix-coiled-coil-helix domain-containing protein 6, mitochondrial, Coiled coil helix cristae morphology protein 1 |
Lieferbar |
|
Manufacturers Product Category |
Primary Antibodies |
Manufacturers Research Category |
Cancer, Cell Cycle |
Short Description |
Boster Bio Anti-MICOS complex subunit MIC25 CHCHD6 Antibody (Catalog # A09965). Tested in ELISA, WB applications. This antibody reacts with Human. |
Description |
Boster Bio Anti-MICOS complex subunit MIC25 CHCHD6 Antibody (Catalog # A09965). Tested in ELISA, WB applications. This antibody reacts with Human. |
Background |
CHCHD6 is a member of a family of proteins containing a conserved (coiled coil 1)-(helix 1)-(coiled coil 2)-(helix 2) domain and has been observed in a complex with the mitochondrial proteins mitofilin, SAM50, metaxins 1 and 2, and CHCHD3. CHCHD6 knockdown causes severe defects in mitochondrial cristae morphology as well as reductions in cell growth, ATP production and oxygen consumption. This decrease of CHCHD6 also led to a reduction in mitofilin protein levels, while a knockdown of mitofilin resulted in a reduced level of CHCHD6, suggesting coordinate regulation between these two proteins. CHCHD6 knockdown in human cancer cells enhances their sensitivity to genotoxic anticancer drugs, suggesting that CHCHD6 may be a potential therapeutic anti-tumor target. |
Gene Name |
CHCHD6 |
Clonality |
Polyclonal |
Concentration |
1 mg/mL |
Contents |
CHCHD6 Antibody is supplied in PBS containing 0.02% sodium azide. |
Application Details |
CHCHD6 antibody can be used for detection of CHCHD6 by Western blot at 1 - 2 μg/mL. Antibody validated: Western Blot in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher. |
Immunogen |
Rabbit polyclonal CHCHD6 antibody was raised against a 17 amino acid peptide near the amino terminus of human CHCHD6. The immunogen is located within amino acids 20 - 70 of CHCHD6. |
Cross-reactivity |
CHCHD6 is predicted to not cross-react to other members of the CHCHD family. |
Purification |
CHCHD6 Antibody is affinity chromatography purified via peptide column. |
Storage |
CHCHD6 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. |
Gene Full Name |
Coiled-coil-helix-coiled-coil-helix domain containing 6 |
Molecular Weight |
26458 MW |
Protein Function |
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. |
Subcellular Localization |
Mitochondrion inner membrane |
Protein Name |
Coiled-coil-helix-coiled-coil-helix domain containing 6 |
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