ArtNr |
BOS-A06336 |
Hersteller |
Boster
|
Menge |
0.1mg |
Format |
Liquid |
Applikationen |
WB, ICC, ELISA |
Specific against |
Human, Mouse, Rat |
Host |
Rabbit |
Isotype |
IgG |
Alias |
Inositol polyphosphate-4-phosphatase type II 105kDa |
Lieferbar |
|
Manufacturers Product Category |
Primary Antibodies |
Manufacturers Research Category |
Cancer, Cell Cycle |
Short Description |
Boster Bio Anti-INPP4B Antibody (Catalog # A06336). Tested in ELISA, WB, ICC applications. This antibody reacts with Human, Mouse, Rat. |
Description |
Boster Bio Anti-INPP4B Antibody (Catalog # A06336). Tested in ELISA, WB, ICC applications. This antibody reacts with Human, Mouse, Rat. |
Background |
Inositol polyphosphate 4-phosphatase type II (INPP4B) is one of the enzymes involved in phosphatidylinositol signaling pathways. It removes the phosphate group at position 4 of the inositol ring from inositol 3, 4-bisphosphate (1). INPP4B can function as a tumor suppressor by inhibiting PI3K signaling. In human epithelial cells, knockdown of INPP4B expression resulted in enhanced Akt activation, anchorage-independent growth, and enhanced overall motility (2). It is thought INPP4B may also have oncogenic functions as INPP4B-dependent PI3K signaling is mediated by SGK3 in breast cancer cells and expression of INPP4B leads to enhanced SGK3 activation and suppression of AKT phosphorylation (3). |
Gene Name |
INPP4B |
Clonality |
Polyclonal |
Concentration |
1 mg/mL |
Contents |
INPP4B antibody is supplied in PBS containing 0.02% sodium azide. |
Application Details |
INPP4B antibody can be used for detection of INPP4B by Western blot at 1 - 2 μg/ml. Antibody can also be used for immunocytochemistry starting at 2.5 μg/mL. Antibody validated: Western Blot in mouse samples and Immunocytochemistry in mouse samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher. |
Immunogen |
INPP4B antibody was raised against a 17 amino acid peptide near the amino terminus of human INPP4B. The immunogen is located within the last 50 amino acids of INPP4B. |
Cross-reactivity |
INPP4B antibody is human, mouse and rat reactive. At least two isoforms of INPP4B are known to exist; this antibody only detects the longer isoform. INPP4B antibody is predicted to not cross-react with INPP4A. |
Purification |
INPP4B antibody is affinity chromatography purified via peptide column. |
Storage |
INPP4B antibody can be stored at 4°C for three months and -20°C, stable for up to one year. |
Gene Full Name |
Inositol polyphosphate-4-phosphatase, type II, 105kDa |
Protein Name |
Inositol polyphosphate-4-phosphatase, type II, 105kDa |
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